Altering the polymorphic product distribution in a solid-state dehydration process by rapid sample rotation in a solid-state NMR probe.

Abstract

There is currently considerable interest in the phenomenon of polymorphism in organic molecular solids, and a key issue in this field is to understand the experimental techniques and procedures that may be employed to obtain new polymorphic forms of a given molecule. This paper demonstrates that the polymorphic form of a material (sodium acetate) obtained by a solid-state dehydration process (starting from sodium acetate trihydrate) can be altered by carrying out the dehydration process under conditions of rapid (several kilohertz) sample rotation in a solid-state magic-angle-spinning NMR probe. This observation suggests a new opportunity to influence the outcome of solid-state dehydration/desolvation processes and, in particular, to alter the polymorphic form of the product obtained.

• Authors: Mingcan Xu, Kenneth D M Harris
• Journal: Journal of the American Chemical Society (J Am Chem Soc) Vol. 127 Issue 31 Pg. 10832-3 (Aug 10 2005) ISSN: 0002-7863 [Print] United States
• PMID: 16076180 (Publication Type: Journal Article)