Abstract | OBJECTIVES: The effectiveness of cisplatinum and vinorelbine (PVn) as a salvage regimen in patients with metastatic breast cancer was reported in previous studies. This report is a pilot study assessing the antitumor efficacy and safety of this regimen as first line therapy for advanced breast cancer patients. METHODS: RESULTS: The overall response rate of our whole population was 74.29%. For the metastatic breast cancer group, the overall response rate was 64%, with a median survival of 19 months (range 2-36). For the locally advanced breast cancer group, the overall response rate was 92.3% with a median time to disease progression of 26 months (range 25-27). Toxicity was acceptable, and no treatment-related mortality was encountered. CONCLUSIONS: PVn is effective as first line treatment of advanced breast cancer with overall response rate of 64% in metastatic breast cancer and 92.3% in locally advanced breast cancer, and acceptable toxicity.
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Authors | Ali Shamseddine, Mohammed Khalifeh, Aref Chehal, Teddy Saliba, Yasser Abou Mourad, Ali Taher, Rahif Jalloul, Nizar Bitar, Azzam Dandashi, Jaber Abbas, Fady B Geara |
Journal | American journal of clinical oncology
(Am J Clin Oncol)
Vol. 28
Issue 4
Pg. 393-8
(Aug 2005)
ISSN: 1537-453X [Electronic] United States |
PMID | 16062082
(Publication Type: Clinical Trial, Phase II, Journal Article)
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Chemical References |
- Vinblastine
- Cisplatin
- Vinorelbine
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Topics |
- Adenocarcinoma
(drug therapy, mortality, pathology, secondary)
- Adult
- Aged
- Antineoplastic Combined Chemotherapy Protocols
(adverse effects, therapeutic use)
- Bone Neoplasms
(secondary)
- Breast Neoplasms
(drug therapy, mortality, pathology)
- Carcinoma, Ductal
(drug therapy, mortality, pathology, secondary)
- Carcinoma, Lobular
(drug therapy, mortality, pathology, secondary)
- Cisplatin
(administration & dosage)
- Female
- Follow-Up Studies
- Humans
- Liver Neoplasms
(secondary)
- Lung Neoplasms
(secondary)
- Lymphatic Metastasis
- Middle Aged
- Neoplasm Staging
- Pilot Projects
- Skin Neoplasms
(secondary)
- Survival Rate
- Treatment Outcome
- Vinblastine
(administration & dosage, analogs & derivatives)
- Vinorelbine
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