Abstract |
The feasibility of one whole liver chemoembolization (CE) procedure with Angiostat, a vasoocclusive collagen, mitomycin, doxorubicin, and cisplatin was evaluated in eight patients with unresectable colorectal carcinoma metastatic to the liver and good performance status. One heavily pretreated patient showed a partial response in the liver lasting 188 days. Five patients had stabilization of the disease for 85-150 days. The side effects of the treatment were considerable with a fatigue syndrome lasting up to eight weeks, chemical and ischemic hepatitis, severe thrombopenia (WHO grade 4 in 2 pts) and icterus being the most disturbing toxicities. We recommend to restrict CE to patients with a life expectancy of more than 4-6 months confined to protocols, which evaluate efficacy, toxicity and influence on quality of life of CE with various cytotoxic drugs. We further suggest to perform staged unilobar CE at 4- to 6-week intervals rather than whole liver CE.
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Authors | M Borner, M Castiglione, J Triller, H U Baer, M Soucek, L Blumgart, K Brunner |
Journal | Annals of oncology : official journal of the European Society for Medical Oncology
(Ann Oncol)
Vol. 3
Issue 2
Pg. 113-5
(Feb 1992)
ISSN: 0923-7534 [Print] England |
PMID | 1606081
(Publication Type: Clinical Trial, Journal Article)
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Chemical References |
- Mitomycins
- Angiostat
- Doxorubicin
- Collagen
- Cisplatin
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Topics |
- Adult
- Aged
- Antineoplastic Combined Chemotherapy Protocols
(therapeutic use)
- Chemoembolization, Therapeutic
(methods)
- Cisplatin
(administration & dosage)
- Collagen
(therapeutic use)
- Colorectal Neoplasms
(pathology, secondary, therapy)
- Doxorubicin
(administration & dosage)
- Female
- Humans
- Liver
(enzymology)
- Liver Neoplasms
(drug therapy, secondary, therapy)
- Male
- Middle Aged
- Mitomycins
(administration & dosage)
- Nausea
(drug therapy, etiology)
- Pain
(drug therapy, etiology)
- Pilot Projects
- Platelet Count
(drug effects)
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