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Considerable side effects of chemoembolization for colorectal carcinoma metastatic to the liver.

Abstract
The feasibility of one whole liver chemoembolization (CE) procedure with Angiostat, a vasoocclusive collagen, mitomycin, doxorubicin, and cisplatin was evaluated in eight patients with unresectable colorectal carcinoma metastatic to the liver and good performance status. One heavily pretreated patient showed a partial response in the liver lasting 188 days. Five patients had stabilization of the disease for 85-150 days. The side effects of the treatment were considerable with a fatigue syndrome lasting up to eight weeks, chemical and ischemic hepatitis, severe thrombopenia (WHO grade 4 in 2 pts) and icterus being the most disturbing toxicities. We recommend to restrict CE to patients with a life expectancy of more than 4-6 months confined to protocols, which evaluate efficacy, toxicity and influence on quality of life of CE with various cytotoxic drugs. We further suggest to perform staged unilobar CE at 4- to 6-week intervals rather than whole liver CE.
AuthorsM Borner, M Castiglione, J Triller, H U Baer, M Soucek, L Blumgart, K Brunner
JournalAnnals of oncology : official journal of the European Society for Medical Oncology (Ann Oncol) Vol. 3 Issue 2 Pg. 113-5 (Feb 1992) ISSN: 0923-7534 [Print] England
PMID1606081 (Publication Type: Clinical Trial, Journal Article)
Chemical References
  • Mitomycins
  • Angiostat
  • Doxorubicin
  • Collagen
  • Cisplatin
Topics
  • Adult
  • Aged
  • Antineoplastic Combined Chemotherapy Protocols (therapeutic use)
  • Chemoembolization, Therapeutic (methods)
  • Cisplatin (administration & dosage)
  • Collagen (therapeutic use)
  • Colorectal Neoplasms (pathology, secondary, therapy)
  • Doxorubicin (administration & dosage)
  • Female
  • Humans
  • Liver (enzymology)
  • Liver Neoplasms (drug therapy, secondary, therapy)
  • Male
  • Middle Aged
  • Mitomycins (administration & dosage)
  • Nausea (drug therapy, etiology)
  • Pain (drug therapy, etiology)
  • Pilot Projects
  • Platelet Count (drug effects)

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