Anicemycin, a new inhibitor of anchorage-independent growth of tumor cells from Streptomyces sp. TP-A0648.

Abstract

The anchorage-independence of cells is closely related to their tumorigenicity. In the screening of inhibitors of anchorage-independent growth of tumor cells, anicemycin was isolated from the fermentation broth of an actinomycete strain TP-A0648. The producing strain was isolated from a leaf of Aucuba japonica collected in Toyama, Japan and identified as Streptomyces sp. based on the taxonomic data. The structure of anicemycin was elucidated as a new analog of spicamycin by NMR and MS analysis. Anicemycin inhibited the anchorage-independent growth of the human ovary cancer SKOV-3 cells with an IC50 of 0.015 microM about three times more potently than their anchorage-dependent growth.

• Authors: Yasuhiro Igarashi, Koushirou Ootsu, Hiroyasu Onaka, Tsuyoshi Fujita, Yoshimasa Uehara, Tamotsu Furumai
• Journal: The Journal of antibiotics (J Antibiot (Tokyo)) Vol. 58 Issue 5 Pg. 322-6 (May 2005) ISSN: 0021-8820 [Print] England
• PMID: 16060384 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Antibiotics, Antineoplastic
• Purine Nucleosides
• anicemycin

Topics

• Antibiotics, Antineoplastic (biosynthesis, chemistry, pharmacology)
• Cell Proliferation (drug effects)
• Chemical Phenomena
• Chemistry, Physical
• Drug Screening Assays, Antitumor
• Fermentation
• Humans
• Magnetic Resonance Spectroscopy
• Mass Spectrometry
• Microscopy, Electron, Scanning
• Models, Molecular
• Plant Leaves (microbiology)
• Purine Nucleosides (biosynthesis, chemistry, pharmacology)
• Spectrophotometry, Ultraviolet
• Streptomyces (classification, metabolism, ultrastructure)
• Structure-Activity Relationship
• Tumor Cells, Cultured