The effects of a novel synthetic retinoid, seletinoid G, on the expression of extracellular matrix proteins in aged human skin in vivo.

Abstract

BACKGROUND:

Although retinoids have potential efficacy in aged skin, their side effect (skin irritation) remains a clinical problem. We designed a novel synthetic retinoid, seletinoid G, by using computer-aided molecular modeling, and investigated its effects on the expression of extracellular matrix proteins in human skin in vivo.

METHODS:

Twenty-three subjects were tested on the buttocks using 4-day occlusive application of seletinoid G and all-trans retinoic acid (tRA). Skin irritation after topical application was quantified by the degree of erythema and cutaneous blood flow. The expression of extracellular matrix proteins and interstitial collagenase (MMP-1) in skin biopsies was investigated by immunohistochemical staining and Western blotting.

RESULTS:

The topical application of seletinoid G under occlusion induced no skin irritation in contrast to tRA, which caused severe erythema. The topical treatment with seletinoid G increased the expressions of type I procollagen, tropoelastin, and fibrillin-1, and reduced MMP-1 in old skin in vivo. Seletinoid G was found to inhibit not only the UV-induced decrease of type I procollagen but the UV-induced increase of MMP-1 and c-Jun protein in young skin in vivo.

CONCLUSIONS:

Seletinoid G is a novel synthetic retinoid, which has little the side effect of skin irritation after topical application. Seletinoid G can repair altered connective tissue in old skin and inhibit UV-induced collagen deficiency in young skin.

• Authors: Mi-Sun Kim, Serah Lee, Ho Sik Rho, Duck Hee Kim, Ih Seop Chang, Jin Ho Chung
• Journal: Clinica chimica acta; international journal of clinical chemistry (Clin Chim Acta) Vol. 362 Issue 1-2 Pg. 161-9 (Dec 2005) ISSN: 0009-8981 [Print] Netherlands
• PMID: 16055107 (Publication Type: Clinical Trial, Journal Article)

Chemical References

• Dioxolanes
• Extracellular Matrix Proteins
• Proto-Oncogene Proteins c-jun
• Pyrans
• Retinoids
• seletinoid G
• Tretinoin
• Matrix Metalloproteinase 1

Topics

• Adult
• Aged
• Dioxolanes (chemical synthesis, chemistry, pharmacology)
• Extracellular Matrix Proteins (metabolism)
• Female
• Gene Expression Regulation (drug effects)
• Humans
• Male
• Matrix Metalloproteinase 1 (metabolism)
• Molecular Structure
• Proto-Oncogene Proteins c-jun (metabolism)
• Pyrans (chemical synthesis, chemistry, pharmacology)
• Retinoids (chemical synthesis, chemistry, pharmacology)
• Skin Aging (drug effects, radiation effects)
• Tretinoin (pharmacology)