Expression of proteoglycan mRNA in patients with painful clicking and chronic closed lock of the temporomandibular joint.

Abstract	RT-PCR was used to analyze the expression of a series of mRNAs coding for proteoglycans aggrecan, versican, biglycan, decorin, fibromodulin and also hyaluronan synthase 1 in specimens obtained during discectomy of the temporomandibular joint in patients with unilateral signs and symptoms of chronic closed lock (eight patients) and painful clicking (seven patients). Regarding the disc, aggrecan expression was higher in patients with chronic closed lock. As for the posterior disc attachment specimens, patients with chronic closed lock showed a tendency for higher expression of biglycan and hyaluronan synthase 1. The degradation of matrix in patients with chronic closed lock of the temporomandibular joint seems not to be caused by a reduced synthesis and the degenerative process seen in these patients is one with low turnover similar to the situation in primary osteoarthrosis of hyaline cartilage. The results indicate that any treatment should intervene early in the disease process of chronic closed lock in order to prevent the development of a degenerative process.
Authors	D I Paegle, A Holmlund, A Hjerpe
Journal	International journal of oral and maxillofacial surgery (Int J Oral Maxillofac Surg) Vol. 34 Issue 6 Pg. 656-8 (Sep 2005) ISSN: 0901-5027 [Print] Denmark
PMID	16053890 (Publication Type: Journal Article)
Chemical References	Aggrecans BGN protein, human Biglycan Chondroitin Sulfate Proteoglycans DCN protein, human Decorin Extracellular Matrix Proteins FMOD protein, human Lectins, C-Type Proteoglycans RNA, Messenger VCAN protein, human Fibromodulin Versicans Glucuronosyltransferase Hyaluronan Synthases
Topics	Adult Aggrecans Analysis of Variance Biglycan Chondroitin Sulfate Proteoglycans (biosynthesis) Chronic Disease Decorin Extracellular Matrix Proteins (biosynthesis) Female Fibromodulin Glucuronosyltransferase (biosynthesis) Humans Hyaluronan Synthases Lectins, C-Type Male Middle Aged Osteoarthritis (metabolism) Proteoglycans (biosynthesis) RNA, Messenger (biosynthesis) Temporomandibular Joint Disc (metabolism, surgery) Temporomandibular Joint Disorders (metabolism) Versicans

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