Abstract |
Laser therapy has been a favoured treatment regime for oral leukoplakia since the mid 1980s. There is no information in the literature regarding factors affecting outcomes in patients with oral leukoplakia. Forty-three patients (mean age 60.3+/-13.6 years) with 73 primary oral leukoplakia were assessed for outcome and factors affecting survival. Dysplastic lesions were found in the majority of patients. The male to female ratio was 1.7:1 with 74% ex- or current smokers, 27% consuming alcohol and 31% continuing to smoke after treatment. The mean observation time was 47.2+/-28.2 months (range 2-102 months). Disease-free survival was 55.4% at 3 years that dropped to 33.9% after 5 years. The malignant transformation rate was 7.3%. No significant prognostic factors were found on univariate analysis but alcohol consumption (P=0.034) and previous malignancy (P=0.018) were found to be significant prognostic indicators using multivariate analysis. Continuation to smoke approached significance (P=0.061). Similar disease-free survival and malignant transformation rates with minimal complications were found as compared to the literature. Recommendations for minimizing recurrence are presented. Long-term follow up and removal of aetiological factors, such as smoking and alcohol, are advised.
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Authors | A Chandu, A C H Smith |
Journal | International journal of oral and maxillofacial surgery
(Int J Oral Maxillofac Surg)
Vol. 34
Issue 4
Pg. 396-400
(Jun 2005)
ISSN: 0901-5027 [Print] Denmark |
PMID | 16053849
(Publication Type: Journal Article)
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Chemical References |
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Topics |
- Adult
- Aged
- Alcohol Drinking
(adverse effects)
- Carbon Dioxide
- Disease-Free Survival
- Female
- Humans
- Laser Therapy
- Leukoplakia, Oral
(surgery)
- Male
- Middle Aged
- Multivariate Analysis
- Neoplasm Recurrence, Local
(etiology)
- Proportional Hazards Models
- Retrospective Studies
- Risk Factors
- Smoking
(adverse effects)
- Treatment Outcome
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