Prophylactic and curative capacity of water soluble formulation of
Diclazuril (Diclosol 1%) and feed additive form (
Clinacox, 0.5%) were tested against Eimeria
infection in broiler chickens. Such testing was performed both experimentally and in the field.
Toltrazuril (
Baycox, 2.5%) was used as reference control drug. Water soluble formulation of
Diclazuril induced a marked inhibitory effect on the different stages of the parasite life cycle in experimentally infected treated birds especially when applied on the day when blood first appeared in the faeces [fifth day post-
infection (d.p.i.)] as well as on the second day of blood dropping (6 d.p.i.). Both tested dosage levels of
Diclazuril water soluble formulation in
drinking water (5 and 10 ppm) showed the same effect in controlling coccidial
infection and reducing the total oocyst numbers, lesion and faecal scores. Moreover, there was no significant difference in the efficacy of water soluble form of
Diclazuril and the reference control drug (
Toltrazuril, 25 ppm). In addition, testing the water soluble formulation (5 ppm) in naturally infected poultry farm (20,000 birds), showed the same anticoccidial effect observed when using
Toltrazuril, as a treatment for
coccidiosis. In conclusion, addition of
Diclazuril at the dose of 5 ppm in the
drinking water of naturally coccidia infected bird induced the same effect as 25 ppm of
Toltrazuril as a treatment for
coccidiosis in chickens.