Abstract | BACKGROUND: METHODS: The mouse FST was performed after single administration of lamotrigine. Subactive doses of lamotrigine were administered in association with subactive doses of the following 5-HT1 receptor agonists or antagonists: 8-hydroxy-2-(di-n-propilamino)-tetralin (8- OH-DPAT, a standard 5-HT(1A) receptor selective agonist), pindolol (a presynaptic and postsynaptic 5-HT(1A/1B) receptor antagonist), NAN-190 (a 5-HT(1A) receptor antagonist), RU 24969 (a 5-HT(1A/1B) receptor agonist) and anpirtoline (5-HT(1B) agonist). RESULTS:
Lamotrigine impaired spontaneous locomotor activity at doses of 4 mg/kg or greater, and activity decreased by more than 50% at the 16 mg/kg dose. When administered alone, lamotrigine (8 and 16 mg/kg) decreased immobility time in the FST. Only 8-OH-DPAT (1 mg/kg), pindolol (32 mg/kg) and RU 24969 (0.5 mg/kg) enhanced the antidepressant-like effect of lamotrigine in the FST. CONCLUSIONS: These results suggest that postsynaptic 5-HT(1A) receptors might be involved in the activity of lamotrigine. Furthermore, they demonstrate that lamotrigine more closely resembles valproate and carbamazepine than lithium, with the advantage of an anti-immobility effect in the mouse FST when administered on its own.
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Authors | Michel Bourin, Fabienne Masse, Martine Hascoët |
Journal | Journal of psychiatry & neuroscience : JPN
(J Psychiatry Neurosci)
Vol. 30
Issue 4
Pg. 275-82
(Jul 2005)
ISSN: 1180-4882 [Print] Canada |
PMID | 16049571
(Publication Type: Journal Article)
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Chemical References |
- Anticonvulsants
- Antimanic Agents
- Receptors, Serotonin
- Triazines
- Lamotrigine
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Topics |
- Animals
- Anticonvulsants
(administration & dosage, pharmacology)
- Antimanic Agents
(administration & dosage, pharmacology)
- Coercion
- Lamotrigine
- Male
- Mice
- Receptors, Serotonin
(drug effects)
- Swimming
- Triazines
(administration & dosage, pharmacology)
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