Abstract | BACKGROUND: METHODS: RESULTS: When the patients were categorized according to these VDR genotypes, serum levels of phosphorus and iPTH and cumulative doses of calcium-based phosphate binders and calcitriol were similar across groups. The corrected serum calcium levels tended to increase in the patients with BsmI non-BB (Bb + bb) variants, but were significantly decreased in the BB variants (9.9 +/- 0.7 vs 9.1 +/- 0.6 mg/dL, p < 0.05). Hypercalcemia appeared in 21.2% of the patients during the follow-up period. The hypercalcemic patients had a significantly higher prevalence of the BsmI non-BB genotype than the normocalcemic patients (85.7% vs 59.6%, p < 0.007). On the contrary, the serum calcium levels were not affected by the TaqI VDR gene polymorphism (p > 0.05). CONCLUSIONS: These findings suggest that the non-BB variants of the BsmI VDR gene polymorphism are associated with increased risk of developing hypercalcemia in PD patients.
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Authors | Ali Akcay, Fatma Nurhan Ozdemir, Siren Sezer, Hasan Micozkadioglu, Zubeyde Arat, Fatma Belgin Atac, Hasibe Verdi, Feride Sahin, Mehmet Haberal |
Journal | Peritoneal dialysis international : journal of the International Society for Peritoneal Dialysis
(Perit Dial Int)
Vol. 25 Suppl 3
Pg. S52-5
(Feb 2005)
ISSN: 0896-8608 [Print] United States |
PMID | 16048257
(Publication Type: Journal Article)
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Chemical References |
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Topics |
- Adult
- Female
- Humans
- Hypercalcemia
(etiology, genetics)
- Kidney Failure, Chronic
(genetics, therapy)
- Male
- Middle Aged
- Peritoneal Dialysis
(adverse effects)
- Polymorphism, Genetic
- Receptors, Calcitriol
(genetics)
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