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TLK-199 (Telik).

Abstract
Telik Inc is developing TLK-199, an intravenous inhibitor of glutathione S-transferase P1-1, for the potential prevention of myelosuppression in blood diseases, namely myelodysplastic syndrome.
AuthorsDavid Hamilton, Gerald Batist
JournalIDrugs : the investigational drugs journal (IDrugs) Vol. 8 Issue 8 Pg. 662-9 (Aug 2005) ISSN: 1369-7056 [Print] England
PMID16044376 (Publication Type: Journal Article)
Chemical References
  • Enzyme Inhibitors
  • Isoenzymes
  • gamma-Glu-S-BzCys-PhGly diethyl ester
  • GSTP1 protein, human
  • Glutathione S-Transferase pi
  • Glutathione Transferase
  • Glutathione
Topics
  • Animals
  • Bone Marrow Diseases (drug therapy, pathology)
  • Enzyme Inhibitors (chemical synthesis, pharmacology, therapeutic use)
  • Glutathione (analogs & derivatives, chemical synthesis, pharmacology, therapeutic use)
  • Glutathione S-Transferase pi
  • Glutathione Transferase (biosynthesis)
  • Humans
  • Isoenzymes (biosynthesis)

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