Angiotensin III as well as angiotensin II regulates water flow through aquaporins in a clam worm.
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| Abstract |
Angiotensin III has been reported to exist in various animals and tissues. The physiological role, however, is still unclear except that brain angiotensin III is a central regulator of vasopressin release. In this study, angiotensin III as well as angiotensin II enhanced an increase in body weight of clam worms of Perinereis sp. under a hypo-osmotic condition and suppressed a decrease in body weight under a hyper-osmotic condition. When clam worms were treated with tetrachloroaurate (III) after angiotensin-treatment, these enhancing and suppressive effects of the angiotensins under hypo- and hyper-osmotic conditions were inhibited. In contrast, when clam worms were pretreated with tetrachloroaurate (III) before angiotensin-treatment, these effects of angiotensins were not inhibited. Since tetrachloroaurate (III) is a representative blocker of aquaporins, these results indicate that angiotensin III as well as angiotensin II regulates water flow through aquaporins in clam worms.
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| Authors | Ryousuke Satou, Tsutomu Nakagawa, Hiroki Ido, Masayuki Tomomatsu, Fumiaki Suzuki, Yukio Nakamura |
| Journal | Bioscience, biotechnology, and biochemistry (Biosci Biotechnol Biochem) Vol. 69 Issue 7 Pg. 1221-5 (Jul 2005) ISSN: 0916-8451 [Print] England |
| PMID | 16041122 (Publication Type: Comparative Study, Journal Article) |
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