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Guidelines for the use of clozapine in individuals with developmental disabilities.

Abstract
Clozapine is the most effective antipsychotic medication currently in use, but there has been a paucity of well-controlled research on its efficacy with people with developmental disabilities. We present a set of guidelines to ensure proper utilization of clozapine in individuals with developmental disabilities, because it can offer them therapeutic advantages similar to those observed in people with schizophrenia. We provide recommendations regarding the use of clozapine that are based on three main sources: literature and published professional practice guidelines regarding the use of clozapine in individuals who do not have developmental disabilities, the limited literature on the use of clozapine in individuals who have developmental disabilities, and our own clinical experience. The first part of the guidelines contains an overview of necessary practical knowledge regarding side effects, dose and blood level considerations, and interactions with other medications, diet and tobacco smoking. In the second part, we offer procedures for selecting individuals for clozapine therapy based on proper indications and contraindications for treatment. We also include requirements regarding informed consent, dosage and special laboratory and clinical monitoring.
AuthorsMohamed Sabaawi, Nirbhay N Singh, Jose de Leon
JournalResearch in developmental disabilities (Res Dev Disabil) 2006 May-Jun Vol. 27 Issue 3 Pg. 309-36 ISSN: 0891-4222 [Print] United States
PMID16040229 (Publication Type: Journal Article, Review)
Chemical References
  • Antipsychotic Agents
  • Clozapine
Topics
  • Adult
  • Antipsychotic Agents (therapeutic use)
  • Child
  • Clinical Trials as Topic
  • Clozapine (therapeutic use)
  • Developmental Disabilities (drug therapy)
  • Female
  • Guidelines as Topic
  • Humans
  • Male

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