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Clinical efficacy of 5-fluorouracil (5-FU) topical cream for treatment of cholesteatoma.

AbstractOBJECTIVE:
In order to clarify clinical efficacy of commercially available 5-fluorouracil (5-FU) topical cream, a clinical study was conducted.
METHODS:
Two to three cubic millimetres of 5-FU topical cream (Kyowa, Roche) was applied on 50 cases of various types of cholesteatoma (50 patients) two to five times with the interval of 2 weeks, and its clinical efficacy was evaluated by the criteria we developed.
RESULTS:
In total, 59% of the cholesteatomas showed good effect, 29% of them showed fair effect, and the effect was poor in the remaining 12%. It was particularly effective in cholesteatomas in the EAC, attic cholesteatomas with an aerated mastoid, and in recurrent-type cholesteatomas.
CONCLUSION:
5-FU topical cream appeared effective for the treatment of cholesteatomas.
AuthorsHaruo Takahashi, Kazuo Funabiki, Seishi Hasebe, Tomomi Fukuda-Yamamoto, Satoru Kaieda, Tetsu Iwanaga, Hidetaka Kumagami, Kenji Takasaki
JournalAuris, nasus, larynx (Auris Nasus Larynx) Vol. 32 Issue 4 Pg. 353-7 (Dec 2005) ISSN: 0385-8146 [Print] Netherlands
PMID16039816 (Publication Type: Journal Article)
Chemical References
  • Antimetabolites, Antineoplastic
  • Fluorouracil
Topics
  • Administration, Topical
  • Adolescent
  • Adult
  • Aged
  • Aged, 80 and over
  • Antimetabolites, Antineoplastic (administration & dosage, therapeutic use)
  • Child
  • Cholesteatoma (drug therapy, pathology)
  • Ear Diseases (drug therapy, pathology)
  • Ear, External (pathology)
  • Female
  • Fluorouracil (administration & dosage, therapeutic use)
  • Humans
  • Male
  • Middle Aged
  • Treatment Outcome

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