[Treatment of postmenopausal osteoporosis with low doses of calcitonin and a calcitonin-anabolic combination].

Abstract

Menopausal osteoporotic women (age: 49-69, mean: 59.5 years) with crush fractures of the spine were treated with low doses of calcitonin (Miacalcic, 350 U/month), or with calcitonin + anabolic steroid (Retabolil, 50 mg/month). Efficacy of the therapy was controlled by single foton absorptiometry of midshaft and distal radius, by X-ray morphometry and by registering new crush fractures of the spine. Calcitonin monotherapy stopped further bone loss for two years, but at the end of the third year both absorptiometric values, as well as the radiomorphometrical index of the lumbar spine decreased significantly. In patients on calcitonin+anabolic steroid the decrease was just significant and only at radius midshaft, while at the other measured sites it was not. Two new crush fractures per 1396 patient-months occurred. Intermittent administration of low-dose calcitonin, especially together with an anabolic steroid seems to be a safe and effective therapy in established osteoporosis.

• Authors: J Szücs, C Horváth, E Kollin, M Szathmári, I Holló
• Journal: Orvosi hetilap (Orv Hetil) Vol. 133 Issue 23 Pg. 1415-8 (Jun 07 1992) ISSN: 0030-6002 [Print] Hungary
• Vernacular Title: Postmenopausás osteoporosis kezelése kis adag kalcitoninnal és kalcitonin-anabolikum kombinációval: 3 éves kezelési tapasztalat.
• PMID: 1603585 (Publication Type: Journal Article)

Chemical References

• Nandrolone
• salmon calcitonin
• Calcitonin
• Nandrolone Decanoate

Topics

• Aged
• Calcitonin (administration & dosage, therapeutic use)
• Drug Therapy, Combination
• Female
• Fractures, Spontaneous (etiology, prevention & control)
• Humans
• Middle Aged
• Nandrolone (administration & dosage, analogs & derivatives)
• Nandrolone Decanoate
• Osteoporosis, Postmenopausal (drug therapy)
• Spinal Fractures (etiology, prevention & control)