The lectin Helix pomatia agglutinin as a marker of metastases--clinical and experimental studies.

Abstract

The prognosis for the majority of patients suffering from a solid neoplasm remains bleak, due to the fact that most cancers have already formed metastases at distant sites. Any progress in cancer therapy will, therefore, depend on the understanding of the metastatic cascade and therapies derived from this understanding. The development of clinically relevant models of metastases, using lectin-defined human cancer cell lines and severe combined immunodeficient (SCID) mice, is described. In conjunction with modern imaging techniques, these models will help to elucidate the molecular mechanisms governing the metastatic spread of tumours.

• Authors: Udo Schumacher, Susan A Brooks, Janos Mester
• Journal: Anticancer research (Anticancer Res) 2005 May-Jun Vol. 25 Issue 3A Pg. 1829-30 ISSN: 0250-7005 [Print] Greece
• PMID: 16033108 (Publication Type: Journal Article)

Chemical References

• Helix lectin
• Lectins

Topics

• Animals
• Cell Line, Tumor
• Humans
• Lectins
• Mice
• Mice, SCID
• Neoplasm Metastasis (diagnosis)