Abstract | BACKGROUND: PATIENTS AND METHODS: Seventy-five carcinomas were evaluated for histological parameters. Tumors were stained immunohistologically for TGF-alpha, c-erbB-2 and factor VIII antigen. Results were analyzed statistically by chi2-test, Kaplan-Meier survival curves and log-rank-test. RESULTS: Sixty-five % of the carcinomas were positive for TGF-alpha in >50% of the tumor cells. C-erbB-2 overexpression occurred in 47% of the tumors, but there was frequently a high cytoplasmatic staining. Twenty-nine % showed high microvessel densitiy. These tumors were more likely to have vascular space involvement (p=0.02). In carcinomas with TGF-alpha expression in >50% of the tumor cells, microvessel density was increased (p=0.05). Overall and disease-free survival tended to be reduced for tumors with high TGF-alpha expression and microvessel density, but differences were not significant. CONCLUSION:
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Authors | Peer Hantschmann, Udo Jeschke, Klaus Friese |
Journal | Anticancer research
(Anticancer Res)
2005 May-Jun
Vol. 25
Issue 3A
Pg. 1731-7
ISSN: 0250-7005 [Print] Greece |
PMID | 16033092
(Publication Type: Journal Article)
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Chemical References |
- Transforming Growth Factor alpha
- Receptor, ErbB-2
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Topics |
- Female
- Humans
- Neovascularization, Pathologic
- Prognosis
- Receptor, ErbB-2
(metabolism)
- Transforming Growth Factor alpha
(metabolism)
- Vulvar Neoplasms
(blood supply, metabolism)
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