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TGF-alpha, c-erbB-2 expression and neoangiogenesis in vulvar squamous cell carcinoma.

AbstractBACKGROUND:
TGF-alpha and c-erbB-2 are important mediators of tumor neoangiogenesis linked to the epidermal growth factor receptor. Thus, we analyzed TGF-alpha c-erbB-2 and tumor neoangiogenesis in vulvar carcinoma and determined their prognostic significance.
PATIENTS AND METHODS:
Seventy-five carcinomas were evaluated for histological parameters. Tumors were stained immunohistologically for TGF-alpha, c-erbB-2 and factor VIII antigen. Results were analyzed statistically by chi2-test, Kaplan-Meier survival curves and log-rank-test.
RESULTS:
Sixty-five % of the carcinomas were positive for TGF-alpha in >50% of the tumor cells. C-erbB-2 overexpression occurred in 47% of the tumors, but there was frequently a high cytoplasmatic staining. Twenty-nine % showed high microvessel densitiy. These tumors were more likely to have vascular space involvement (p=0.02). In carcinomas with TGF-alpha expression in >50% of the tumor cells, microvessel density was increased (p=0.05). Overall and disease-free survival tended to be reduced for tumors with high TGF-alpha expression and microvessel density, but differences were not significant.
CONCLUSION:
Tumor neoangiogenesis is an important event in vulvar carcinogenesis which is related to the expression of growth factors.
AuthorsPeer Hantschmann, Udo Jeschke, Klaus Friese
JournalAnticancer research (Anticancer Res) 2005 May-Jun Vol. 25 Issue 3A Pg. 1731-7 ISSN: 0250-7005 [Print] Greece
PMID16033092 (Publication Type: Journal Article)
Chemical References
  • Transforming Growth Factor alpha
  • Receptor, ErbB-2
Topics
  • Female
  • Humans
  • Neovascularization, Pathologic
  • Prognosis
  • Receptor, ErbB-2 (metabolism)
  • Transforming Growth Factor alpha (metabolism)
  • Vulvar Neoplasms (blood supply, metabolism)

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