Analgesic effects of nonsteroidal antiinflammatory drugs, acetaminophen, and morphine in a mouse model of bone cancer pain.

Abstract

PURPOSE:

Bone metastasis is one of the major causes of cancer-related pain, and not all bone cancer pain can be effectively treated. Recently, a mouse model of bone cancer pain was introduced. To test the analgesic effects of nonsteroidal antiinflammatory drugs on bone cancer pain, the authors examined the effects of oral administration of a cyclooxygenase-1 (COX-1) selective inhibitor (SC560), a COX-2 selective inhibitor (celecoxib), and a nonselective COX inhibitor (indomethacin) on bone cancer pain and compared these effects to the effect of orally administered acetaminophen and morphine.

METHODS:

An animal model of bone cancer pain was induced by injecting osteolytic murine sarcoma cells in the mouse femur. Drugs were administered orally 2 weeks after tumor-cell implantation, and the level of bone cancer pain was assessed 30, 60, 90, 120, and 180 min after drug administration.

RESULTS:

Oral administration of acetaminophen, indomethacin, and morphine, but not of SC560 or celecoxib, produced an analgesic effect on bone cancer pain. Co-administration of a subanalgesic does of morphine with acetaminophen enhanced the analgesic effect of acetaminophen.

CONCLUSION:

These data suggest that bone cancer pain is effectively treated by oral administration of indomethacin, acetaminophen, and morphine and that the co-administration of acetaminophen and an opioid provides a beneficial effect when treating of bone cancer pain.

• Authors: Osamu Saito, Tomohiko Aoe, Tatsuo Yamamoto
• Journal: Journal of anesthesia (J Anesth) Vol. 19 Issue 3 Pg. 218-24 ( 2005) ISSN: 0913-8668 [Print] Japan
• PMID: 16032450 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Analgesics, Non-Narcotic
• Analgesics, Opioid
• Anti-Inflammatory Agents, Non-Steroidal
• Cyclooxygenase 2 Inhibitors
• Cyclooxygenase Inhibitors
• Membrane Proteins
• Acetaminophen
• Morphine
• Cyclooxygenase 1
• Cyclooxygenase 2
• Prostaglandin-Endoperoxide Synthases
• Ptgs1 protein, mouse

Topics

• Acetaminophen (therapeutic use)
• Analgesics, Non-Narcotic (therapeutic use)
• Analgesics, Opioid (therapeutic use)
• Animals
• Anti-Inflammatory Agents, Non-Steroidal (therapeutic use)
• Bone Neoplasms (complications, pathology)
• Bone and Bones (pathology)
• Cyclooxygenase 1
• Cyclooxygenase 2
• Cyclooxygenase 2 Inhibitors
• Cyclooxygenase Inhibitors (therapeutic use)
• Dose-Response Relationship, Drug
• Drug Therapy, Combination
• Male
• Membrane Proteins
• Mice
• Mice, Inbred C3H
• Morphine (therapeutic use)
• Neoplasm Transplantation
• Pain (drug therapy, etiology)
• Pain Measurement (drug effects)
• Prostaglandin-Endoperoxide Synthases (metabolism)
• Sarcoma (complications, pathology)