Abstract | OBJECTIVE: PATIENTS AND METHODS:
VEGF levels in pleural effusions collected from 52 patients (20 with malignant effusion, 12 with tuberculous effusion, 10 with transudative effusion, and 10 with parapneumonic effusion) were assessed by enzyme-linked immunosorbent assay. RESULTS: The median level of VEGF was significantly higher (P = .001) in exudative effusions (10.16 pg/mL) than in the transudative effusions (3.82 pg/mL). Although malignant pleural fluids tended to have higher median and mean levels of VEGF compared to tuberculous effusions, the difference was not statistically significant. Pleural VEGF levels in subtypes of lung cancer and in malignant effusions of different origins were not significantly different. CONCLUSIONS: In conclusion, although VEGF levels in pleural effusions of different origins vary, they were only able to discriminate exudates from transudates significantly in this study. Further studies in larger groups of patients are needed to establish the role of VEGF in diagnosing malignant and/or tuberculous effusions.
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Authors | A Kaya, B Poyraz, G Celik, A Ciledag, B E Gulbay, H Savas, I Savas |
Journal | Archivos de bronconeumologia
(Arch Bronconeumol)
Vol. 41
Issue 7
Pg. 376-9
(Jul 2005)
ISSN: 0300-2896 [Print] Spain |
Vernacular Title | El factor de crecimiento endotelial vascular en los derrames pleurales benignos y malignos. |
PMID | 16029730
(Publication Type: English Abstract, Journal Article)
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Chemical References |
- Vascular Endothelial Growth Factor A
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Topics |
- Biopsy
- Enzyme-Linked Immunosorbent Assay
- Exudates and Transudates
(microbiology)
- Female
- Humans
- Lung Neoplasms
(epidemiology, pathology)
- Male
- Mycobacterium Infections
(complications)
- Mycobacterium tuberculosis
(isolation & purification)
- Pleural Effusion
(metabolism)
- Pleural Effusion, Malignant
(epidemiology, metabolism, microbiology)
- Pneumonia
(epidemiology)
- Prospective Studies
- Severity of Illness Index
- Vascular Endothelial Growth Factor A
(metabolism)
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