Abstract | BACKGROUND: The inflammation in acne vulgaris is widely thought to be induced by an immunological reaction, but the role of Propionibacterium acnes is unclear. OBJECTIVES: To examine the local host response mechanism of a keratinocyte cell line 3 h and 6 h after stimulation with viable and heat-killed P. acnes. METHODS: The quantitative expression of cytokines was measured at the mRNA level by real-time reverse transcription-polymerase chain reaction. RESULTS: CONCLUSIONS: This cytokine pattern may favour a chemotactic response and implicates P. acnes and coproporphyrin III in the recruitment of inflammatory cells to the site of infection and in the development of acne lesions.
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Authors | M Schaller, M Loewenstein, C Borelli, K Jacob, M Vogeser, W H C Burgdorf, G Plewig |
Journal | The British journal of dermatology
(Br J Dermatol)
Vol. 153
Issue 1
Pg. 66-71
(Jul 2005)
ISSN: 0007-0963 [Print] England |
PMID | 16029328
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Antigens, Bacterial
- Chemotactic Factors
- Coproporphyrins
- Cytokines
- Inflammation Mediators
- RNA, Messenger
- coproporphyrin III
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Topics |
- Acne Vulgaris
(immunology, metabolism, microbiology)
- Adolescent
- Adult
- Antigens, Bacterial
(immunology)
- Cell Line
- Chemotactic Factors
(immunology)
- Coproporphyrins
(biosynthesis, immunology)
- Cytokines
(biosynthesis, genetics, immunology)
- Humans
- Inflammation Mediators
(metabolism)
- Keratinocytes
(immunology)
- Propionibacterium acnes
(immunology)
- RNA, Messenger
(genetics)
- Reproducibility of Results
- Reverse Transcriptase Polymerase Chain Reaction
(methods)
- Skin
(metabolism)
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