[Evaluation of the influence of the bacterial vaccines Pneumo-23 and Act-HIB on the course of the chronic inflammatory process of the respiratory organs in children].

Abstract

The effectiveness and safety of vaccination of children having chronic inflammatory lung diseses with Pneumo-23 and Act-HIB were evaluated. The group under study included 38 children having chronic pneumonia, congenital defects of lung development, Kartagener's syndrome, mucoviscidosis; of these children, 25 were vaccinated with Pneumo-23 and 13--with Act-HIB. For comparison a group of 40 children with the same pathology, but not vaccinated, was used. A favorable course of the postvaccinal period was noted. Prior to vaccination Streptococcus pneumoniae in association with Haemophilus influenzae were isolated from all patients; in a year after vaccination with Pneumo-23 these microorganisms were isolated only in monoculture: S. pneumoniae in 3 out of 25 cases (88% elimination) and H. influenzae in 10 out of 25 cases (60% elimination).

• Authors: A A Ryzhov, L K Katosova, M P Kostinov, I K Volkov, O O Magarshak
• Journal: Zhurnal mikrobiologii, epidemiologii i immunobiologii (Zh Mikrobiol Epidemiol Immunobiol) 2005 May-Jun Issue 3 Pg. 84-7 ISSN: 0372-9311 [Print] Russia (Federation)
• PMID: 16028524 (Publication Type: Clinical Trial, Comparative Study, Journal Article, Randomized Controlled Trial)

Chemical References

• 23-valent pneumococcal capsular polysaccharide vaccine
• Haemophilus Vaccines
• Haemophilus influenzae type b polysaccharide vaccine
• Pneumococcal Vaccines
• Polysaccharides, Bacterial
• Vaccines, Acellular
• Vaccines, Conjugate

Topics

• Adolescent
• Bacterial Capsules
• Child
• Child, Preschool
• Chronic Disease
• Haemophilus Infections (microbiology, prevention & control)
• Haemophilus Vaccines (administration & dosage)
• Haemophilus influenzae (isolation & purification)
• Humans
• Pneumococcal Infections (microbiology, prevention & control)
• Pneumococcal Vaccines (administration & dosage)
• Pneumonia, Bacterial (microbiology, prevention & control)
• Polysaccharides, Bacterial (administration & dosage)
• Respiratory Tract Infections (microbiology, prevention & control)
• Streptococcus pneumoniae (isolation & purification)
• Vaccines, Acellular (administration & dosage)
• Vaccines, Conjugate (administration & dosage)