Effect of insulin on NO production by monocytes from patients with metabolic cardiovascular syndrome.

Abstract

Basal and insulin-induced production of NO by monocytes significantly increased in patients with metabolic cardiovascular syndrome. Plasma insulin concentration in these patients was below the control. No intergroup differences were found in C-peptide concentration. A negative correlation was revealed between insulin-induced NO production by monocytes and C-peptide/insulin ratio in patients. The role of monocytes on the regulation of vascular tone via NO production in patients with metabolic cardiovascular syndrome is discussed.

• Authors: T E Suslova, A V Sitozhevskii, O N Ogurkova, O V Gruzdeva, T S Fedorova, R S Karpov
• Journal: Bulletin of experimental biology and medicine (Bull Exp Biol Med) Vol. 139 Issue 4 Pg. 391-3 (Apr 2005) ISSN: 0007-4888 [Print] United States
• PMID: 16027861 (Publication Type: Journal Article)

Chemical References

• Insulin
• Nitric Oxide

Topics

• Humans
• Insulin (pharmacology)
• Male
• Metabolic Syndrome (metabolism)
• Middle Aged
• Monocytes (metabolism)
• Nitric Oxide (biosynthesis)