Prooxidant-antioxidant balance in the prostate and blood of rats with sulpyride[corrected]-induced prostatic hyperplasia corrected with prostatilen.

Abstract

We studied the effects of 30-day injections of sulpyride and treatment with Prostatilen on the development of prostatic hyperplasia and LPO in rats. Sulpyride induced proliferation of lateral lobes, increased the content of lipid hydroperoxides and glutathione peroxidase activity in the gland; in the blood this preparation increased lipid hydroperoxide concentration and decreased glutathione peroxidase and total antioxidant activity. Prostatilen prevented the development of hyperplasia and normalized the prooxidant-antioxidant balance in tissues, except total antioxidant activity of the blood.

• Authors: L I Belostotskaya, O N Gomon, Yu V Nikitchenko, L A Chaika, V V Bondar, V N Dzyuba
• Journal: Bulletin of experimental biology and medicine (Bull Exp Biol Med) Vol. 139 Issue 3 Pg. 334-6 (Mar 2005) ISSN: 0007-4888 [Print] United States
• PMID: 16027846 (Publication Type: Comparative Study, Journal Article)

Chemical References

• Lipid Peroxides
• Peptides
• prostatilen
• Sulpiride
• Glutathione Peroxidase

Topics

• Animals
• Glutathione Peroxidase (blood, metabolism)
• Lipid Peroxides (blood, metabolism)
• Male
• Oxidation-Reduction
• Peptides (therapeutic use)
• Prostatic Hyperplasia (blood, chemically induced, enzymology, metabolism, prevention & control)
• Rats
• Rats, Inbred Strains
• Sulpiride