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Single intratumoral injection of long-acting benzyl ester of D-penicillamine inhibits the growth of melanoma tumor in mice.

Abstract
Using a murine model of melanoma we tested the effect of D-penicillamine administered in repetitive, daily injections, or as a single large dose injected either in saline or in a biodegradable polymer. We also studied the effect of a single intratumoral injection of benzyl-ester-D-penicillamine on the growth of the tumor. Daily injections of the drug or its administration in a polymer or benzyl-ester of D-penicillamine were all significantly inhibitory. The inhibitory effect manifested 4-5 days after injection. The inhibition lasted 8-10 days. There was no evidence of local or systemic toxicity and no changes in body weight. Several possible mechanisms for the inhibitory effect are presented.
AuthorsMilos Chvapil, Robert Dorr
JournalAnti-cancer drugs (Anticancer Drugs) Vol. 16 Issue 7 Pg. 757-62 (Aug 2005) ISSN: 0959-4973 [Print] England
PMID16027526 (Publication Type: Journal Article)
Chemical References
  • Antineoplastic Agents
  • Delayed-Action Preparations
  • Esters
  • penicillamine benzyl ester
  • Penicillamine
Topics
  • Animals
  • Antineoplastic Agents (administration & dosage, adverse effects, therapeutic use)
  • Delayed-Action Preparations
  • Drug Administration Schedule
  • Esters
  • Female
  • Injections, Intralesional
  • Melanoma, Experimental (drug therapy)
  • Mice
  • Mice, Inbred C57BL
  • Penicillamine (administration & dosage, adverse effects, analogs & derivatives, pharmacology)

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