Abstract |
Using a murine model of melanoma we tested the effect of D-penicillamine administered in repetitive, daily injections, or as a single large dose injected either in saline or in a biodegradable polymer. We also studied the effect of a single intratumoral injection of benzyl-ester-D-penicillamine on the growth of the tumor. Daily injections of the drug or its administration in a polymer or benzyl- ester of D-penicillamine were all significantly inhibitory. The inhibitory effect manifested 4-5 days after injection. The inhibition lasted 8-10 days. There was no evidence of local or systemic toxicity and no changes in body weight. Several possible mechanisms for the inhibitory effect are presented.
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Authors | Milos Chvapil, Robert Dorr |
Journal | Anti-cancer drugs
(Anticancer Drugs)
Vol. 16
Issue 7
Pg. 757-62
(Aug 2005)
ISSN: 0959-4973 [Print] England |
PMID | 16027526
(Publication Type: Journal Article)
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Chemical References |
- Antineoplastic Agents
- Delayed-Action Preparations
- Esters
- penicillamine benzyl ester
- Penicillamine
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Topics |
- Animals
- Antineoplastic Agents
(administration & dosage, adverse effects, therapeutic use)
- Delayed-Action Preparations
- Drug Administration Schedule
- Esters
- Female
- Injections, Intralesional
- Melanoma, Experimental
(drug therapy)
- Mice
- Mice, Inbred C57BL
- Penicillamine
(administration & dosage, adverse effects, analogs & derivatives, pharmacology)
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