HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Alcoholic turmeric extract simultaneously activating murine lymphocytes and inducing apoptosis of Ehlrich ascitic carcinoma cells.

Abstract
In the present investigation ethanolic turmeric extract has been found to play diabolically opposite role on murine lymphocytes and on Ehlrich ascitic carcinoma cells. Turmeric stimulates the lymphocytes into the effector pathway as studied through in vitro viability, blastogenesis and (3)H-TdR incorporation and also seems to be healthy under scanning electron microscopy (SEM). SEM revealed the formation of cytoplasmic blebs and plasma membrane disintegration of tumor cells with ethanolic turmeric extract treatment, suggesting turmeric to be initiating apoptosis of tumor cells. Thus, in the present work viability of the cells, blastogenesis, DNA synthesis and SEM study establish the fact that turmeric is a conducive agent for lymphocytes and inhibitory as well as apoptotic for tumor cells.
AuthorsAshim Kumar Chakravarty, Hadida Yasmin
JournalInternational immunopharmacology (Int Immunopharmacol) Vol. 5 Issue 10 Pg. 1574-81 (Sep 2005) ISSN: 1567-5769 [Print] Netherlands
PMID16023609 (Publication Type: Comparative Study, Journal Article)
Chemical References
  • Antioxidants
  • Plant Extracts
  • Ethanol
  • turmeric extract
Topics
  • Animals
  • Antioxidants (pharmacology)
  • Apoptosis
  • B-Lymphocytes (drug effects, immunology)
  • Cell Line, Tumor
  • Cell Proliferation (drug effects)
  • Cell Survival (drug effects)
  • Curcuma
  • Ethanol
  • Female
  • Lymph Nodes (cytology, immunology)
  • Lymphocyte Activation (drug effects)
  • Male
  • Mice
  • Microscopy, Electron, Scanning
  • Plant Extracts (pharmacology)
  • Spleen (cytology, immunology, ultrastructure)
  • T-Lymphocytes (drug effects, immunology)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: