2-(1-Hexyn-1-yl)adenosine-induced intraocular hypertension is mediated via K+ channel opening through adenosine A2A receptor in rabbits.

Abstract

The present study was performed to clarify the mechanism of change in intraocular pressure by 2-(1-hexyn-1-yl)adenosine (2-H-Ado), a selective adenosine A2 receptor agonist, in rabbits. 2-H-Ado (0.1%, 50 microl)-induced ocular hypertension (E(max): 7.7 mm Hg) was inhibited by an adenosine A2A receptor antagonist 1,3,7-trimethyl-8-(3-chlorostyryl)xanthine, ATP-sensitive K+ channel blocker glibenclamide or 5-hydroxydecanoic acid, but not by an adenosine A1 receptor antagonist 8-cyclopentyl-1,3-dipropylxanthine, an adenosine A2B receptor antagonist alloxazine or a cyclooxygenase inhibitor indomethacin. The outflow facility induced by 2-H-Ado seems to be independent of increase in intraocular pressure or ATP-sensitive K+ channel. In contrast, the recovery rate in intraocular pressure decreased by hypertonic saline was accelerated by 2-H-Ado, and this response was dependent on ATP-sensitive K+ channel. These results suggest that 2-H-Ado-induced ocular hypertension is mediated via K+ channel opening through adenosine A2A receptor, and this is probably due to aqueous formation, but independent of change in outflow facility or prostaglandin production.

• Authors: Takashi Konno, Takehiro Uchibori, Akihiko Nagai, Kentaro Kogi, Norimichi Nakahata
• Journal: European journal of pharmacology (Eur J Pharmacol) Vol. 518 Issue 2-3 Pg. 203-11 (Aug 22 2005) ISSN: 0014-2999 [Print] Netherlands
• PMID: 16023100 (Publication Type: Comparative Study, Journal Article)

Chemical References

• Adenosine A2 Receptor Agonists
• Adenosine A2 Receptor Antagonists
• Alkynes
• Antihypertensive Agents
• Decanoic Acids
• Hydroxy Acids
• Hypotonic Solutions
• Phenethylamines
• Potassium Channel Blockers
• Potassium Channels
• Receptor, Adenosine A2A
• Xanthines
• 2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine
• 8-(3-chlorostyryl)caffeine
• Caffeine
• N(6)-cyclopentyladenosine
• Sodium Chloride
• 5-hydroxydecanoic acid
• Pinacidil
• 2-hexynyladenosine
• 1,3-dipropyl-8-cyclopentylxanthine
• Adenosine
• Glyburide

Topics

• Adenosine (analogs & derivatives, pharmacology)
• Adenosine A2 Receptor Agonists
• Adenosine A2 Receptor Antagonists
• Alkynes (pharmacology)
• Animals
• Antihypertensive Agents (pharmacology)
• Caffeine (analogs & derivatives, pharmacology)
• Decanoic Acids (pharmacology)
• Glyburide (pharmacology)
• Hydroxy Acids (pharmacology)
• Hypotonic Solutions (pharmacology)
• Intraocular Pressure (drug effects, physiology)
• Male
• Ocular Hypertension (chemically induced, physiopathology, prevention & control)
• Phenethylamines (pharmacology)
• Pinacidil (pharmacology)
• Potassium Channel Blockers (pharmacology)
• Potassium Channels (physiology)
• Rabbits
• Receptor, Adenosine A2A (physiology)
• Sodium Chloride (pharmacology)
• Time Factors
• Xanthines (pharmacology)