Abstract |
The discovery of a second receptor for prostaglandin D2, chemoattractant receptor-homologous molecule expressed on T helper type 2 (CRTH2), has revived significant efforts into the development of small-molecule antagonists for allergic diseases as the receptor is predominantly expressed on cells such as eosinophils, TH2 cells and basophils, which are major pro-inflammatory cells in diseases such as asthma and allergic rhinitis. This brief review serves to illustrate current patent literature focusing on the similarities and differences of an ever-growing number of CRTH2 antagonists emerging from corporate laboratories.
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Authors | Tai Wei Ly, Kevin B Bacon |
Journal | Expert opinion on investigational drugs
(Expert Opin Investig Drugs)
Vol. 14
Issue 7
Pg. 769-73
(Jul 2005)
ISSN: 1744-7658 [Electronic] England |
PMID | 16022566
(Publication Type: Editorial, Review)
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Chemical References |
- Inflammation Mediators
- Prostaglandin Antagonists
- Receptors, Immunologic
- Receptors, Prostaglandin
- prostaglandin D2 receptor
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Topics |
- Animals
- Humans
- Hypersensitivity
(drug therapy, immunology, pathology)
- Inflammation Mediators
(antagonists & inhibitors, physiology)
- Prostaglandin Antagonists
(pharmacology, therapeutic use)
- Receptors, Immunologic
(antagonists & inhibitors, physiology)
- Receptors, Prostaglandin
(antagonists & inhibitors, physiology)
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