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PST 2238 as an antihypertensive compound that antagonizes the effect of endogenous cardiac glycosides.

Abstract
This review examines the role of endogenous cardiac glycosides (OLF--ouabain like factors) in the pathogenesis of hypertension. The discovery of ouabain as a new adrenal hormone affecting salt and water homeostasis has initiated research on a new group of compounds. OLF may provide new insights into the mechanisms and therapy of common cardiovascular diseases. PST 2238 (17beta-(3-furyl)-5beta-androstane-3beta-14beta-17alpha-triol), an antagonist of endogenous ouabain, might open new possibilities for the therapy of hypertension and congestive heart failure.
AuthorsKatarzyna Winnicka, Marian Tomasiak
JournalActa poloniae pharmaceutica (Acta Pol Pharm) 2005 Jan-Feb Vol. 62 Issue 1 Pg. 75-9 ISSN: 0001-6837 [Print] Poland
PMID16022498 (Publication Type: Journal Article, Review)
Chemical References
  • Androstanols
  • Antihypertensive Agents
  • Cardiac Glycosides
  • Ouabain
  • rostafuroxin
Topics
  • Androstanols (pharmacology)
  • Animals
  • Antihypertensive Agents (pharmacology)
  • Cardiac Glycosides (antagonists & inhibitors)
  • Humans
  • Hypertension (physiopathology)
  • Ouabain (antagonists & inhibitors)

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