| Abstract | Clinical and experimental studies provide evidence that the plasminogen activation system plays a pivotal role in the pathogenesis of tumor growth and metastatic spread. The aim of the present study was to evaluate plasminogen activator inhibitor type I (PAI-1) in plasma and tumor extracts in patients with non-small cell lung cancer (NSCLC). The study group consisted of 146 patients (18 females, 128 males), aged 33-76 years with squamous cell carcinoma (107), adenocarcinoma (19), and mixed type of lung carcinoma (20) in pTNM stage I (72), stage II (30) and stage III (44) and 50 healthy volunteers as a control group (15 females, 35 males) aged 25-69 years. Blood for analysis was collected in the morning, 1-2 days before operation. Lung cancer and normal lung tissue specimens were obtained during surgery and homogenized in liquid nitrogen. The tissue extracts and plasma were assayed for concentration of PAI-1 with ELISA method. Significantly higher plasma level of PAI-1 was observed in patients with lung cancer than in control group. Concentration of PAI-1 in tumor tissues was significantly higher compared to normal lung tissue and was irrelevant from plasma level. Positive correlation between tumor level of PAI-1 and stage of lung cancer was noticed. Therefore it can be assumed that PAI-1 has an influence on the lung cancer progression. |
| Authors | Ewa Zekanowska, Krzysztof Cieśliński, Danuta Rość
(Affiliation: Katedra Patofizjologii Akademii Medycznej w Bydgoszczy. kizpatofiz at amb.bydgoszcz.pl)
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| Journal | Pneumonologia i alergologia polska : organ Polskiego Towarzystwa Ftyzjopneumonologicznego, Polskiego Towarzystwa Alergologicznego, i Instytutu Gruźlicy i Chorób Płuc
(Pneumonol Alergol Pol)
Vol. 72
Issue 9-10
Pg. 409-14
( 2004)
ISSN: 0867-7077 Poland |
| Vernacular Title | Inhibitor aktywatorów plazminogenu typu 1 (PAI-1) we krwi oraz ekstraktach tkankowych chorych na niedrobnokomórkowego raka płuca. |
| PMID | 16021996
(Publication Type: English Abstract, Journal Article)
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| Chemical References |
- Plasminogen Activator Inhibitor 1
|
| Topics |
- Adenocarcinoma
(blood, chemistry)
- Adult
- Aged
- Carcinoma, Non-Small-Cell Lung
(blood, chemistry, pathology)
- Carcinoma, Squamous Cell
(blood, chemistry)
- Case-Control Studies
- Enzyme-Linked Immunosorbent Assay
- Female
- Humans
- Lung Neoplasms
(blood, chemistry, pathology)
- Male
- Middle Aged
- Neoplasm Staging
- Plasminogen Activator Inhibitor 1
(analysis, blood)
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