| Abstract | OBJECTIVE: Does the use of nifedipine and magnesium sulfate together increase serious magnesium-related effects? STUDY DESIGN: This was a retrospective chart review of women who were admitted to BC Women's Hospital and Health Centre (1997-2001) and were given intravenous magnesium sulfate for preeclampsia. Serious magnesium-related effects were compared among 162 cases who received magnesium sulfate and contemporaneous nifedipine and 215 control subjects who received magnesium sulfate and either another antihypertensive (n=32 women) or no antihypertensive (n=183 women) medication. Chi-squared test, Fisher's exact test, or the Student t test was used for data comparison between cases and each control group. A probability value of <.05 was considered statistically significant. RESULTS: The cases had more severe preeclampsia and a longer magnesium sulfate infusion. However, cases had no excess of neuromuscular weakness (53.1%) versus control subjects who received antihypertensive medication (53.1%; P=.99) or control subjects who received no antihypertensive medication (44.8%; P=.13) or other serious magnesium-related effects. Cases versus control subjects who received antihypertensive medication had less neuromuscular blockade (odds ratio, 0.04; 95% CI, 0.002-0.80). Cases versus control subjects who received no antihypertensive medication had less maternal hypotension (41.4% vs 53.0%; P=.04). CONCLUSION: The use of nifedipine and magnesium sulfate together does not increase the risk of serious magnesium-related effects. |
| Authors | Laura A Magee, Saman Miremadi, Jing Li, Carol Cheng, Mary H H Ensom, Bruce Carleton, Anne-Marie Côté, Peter von Dadelszen
(Affiliation: Centre for Healthcare Innovation and Improvement, British Columbia Research Institute for Children's and Women's Health, Department of Specialized Women's Health, BC Women's Hospital and Health Centre, Canada. LMagee at cw.bc.ca)
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| Journal | American journal of obstetrics and gynecology
(Am J Obstet Gynecol)
Vol. 193
Issue 1
Pg. 153-63
(Jul 2005)
ISSN: 0002-9378 United States |
| PMID | 16021073
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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| Chemical References |
- Antihypertensive Agents
- Calcium Channel Blockers
- Nifedipine
- Magnesium Sulfate
|
| Topics |
- Adult
- Antihypertensive Agents
(therapeutic use)
- Calcium Channel Blockers
(therapeutic use)
- Case-Control Studies
- Cohort Studies
- Drug Therapy, Combination
- Female
- Humans
- Incidence
- Injections, Intravenous
- Magnesium Sulfate
(administration & dosage, adverse effects, therapeutic use)
- Neuromuscular Diseases
(chemically induced, epidemiology)
- Nifedipine
(therapeutic use)
- Pre-Eclampsia
(drug therapy)
- Pregnancy
- Retrospective Studies
- Risk
|
