Abstract | BACKGROUND: METHODS: The HO-1 gene GT dinucleotide repeat promoter polymorphism and HO-1 +99G/C variant were evaluated in 199 patients with coronary artery disease after coronary stent implantation and control angiography at 6 months after the intervention. Coronary restenosis was confirmed by quantitative angiography. RESULTS: Carriers of the long allele of the HO-1 gene promoter (>29 repeats) had a significantly higher risk of developing restenosis after PCI than noncarriers [odds ratio (OR)=1.9; 95% confidence interval (95% CI), 1.0-3.4; P=0.04]. Interestingly, the allele longer than 29 repeats conferred a significantly higher risk of developing restenosis (OR=3.4; 95% CI, 1.2-9.1; P=0.017) in nonsmokers than in smokers (OR=2.0; 95% CI, 0.7-5.2; P=0.18). CONCLUSIONS: The long allele of the HO-1 gene promoter (>29 repeats) polymorphism, which leads to low HO-1 inducibility, may represent an independent prognostic marker for restenosis after PCI and stent implantation. The effect of the >29 repeat allele is attenuated in smokers, who have chronic exogenous CO exposure.
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Authors | Talin Gulesserian, Catharina Wenzel, Georg Endler, Raute Sunder-Plassmann, Claudia Marsik, Christine Mannhalter, Nelly Iordanova, Mariann Gyöngyösi, Johann Wojta, Stefan Mustafa, Oswald Wagner, Kurt Huber |
Journal | Clinical chemistry
(Clin Chem)
Vol. 51
Issue 9
Pg. 1661-5
(Sep 2005)
ISSN: 0009-9147 [Print] England |
PMID | 16020495
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Isoenzymes
- Membrane Proteins
- HMOX1 protein, human
- Heme Oxygenase (Decyclizing)
- Heme Oxygenase-1
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Topics |
- Aged
- Amino Acid Substitution
- Angioplasty, Balloon, Coronary
(adverse effects)
- Coronary Restenosis
(etiology, genetics)
- Cross-Sectional Studies
- Female
- Genotype
- Heme Oxygenase (Decyclizing)
(genetics)
- Heme Oxygenase-1
- Humans
- Isoenzymes
(genetics)
- Male
- Membrane Proteins
- Middle Aged
- Polymorphism, Genetic
- Promoter Regions, Genetic
- Risk Assessment
- Smoking
(adverse effects)
- Stents
(adverse effects)
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