Cicatricial pemphigoid is the most common of the immunobullous disorders causing conjunctival
cicatrization and is an
autoimmune disease in which the ocular component of the immunopathology is directed at the conjunctival basement membrane. The disease is usually bilateral and more common in females, with most cases occurring between 30-90 years, and most often in the seventh decade. The disease occasionally occurs in children. Tear deficiency is a major cause of symptoms, although loss of vision is usually due to surface failure before the onset of aqueous tear deficiency, which occurs late in the progression of the disease. Management of the
dry eye must be integrated with the management of the other components of both the ocular surface disease and
inflammation. Management requires plastic surgery for the lid and lash malposition,
tetracyclines and lid hygiene for the accompanying
blepharitis. For the
dry eye, the use of
lubricants without preservatives is important, to avoid toxicity, and
lubricant ointment is helpful for the relief of symptoms in terminally
dry eyes without the capacity for surface wetting.
Contact lenses, either large limbal diameter rigid gas permeable or gas permeable scleral
lenses, are useful for treating
dry eye and improving vision in some patients. Control of the conjunctival
inflammation is mandatory to prevent
disease progression and usually requires systemic immunosuppressive therapy.