NCOR1 mRNA is an independent prognostic factor for breast cancer.

Abstract

The transcriptional function of estrogen receptor alpha (ERalpha) can be modulated by co-regulatory proteins. In the present study, therefore, the level of expression of one of the co-regulator Nuclear Receptor Co-repressor 1 (NCOR1) mRNA has been assessed by quantitative real-time RT-PCR in 160 cases of invasive breast carcinoma. It was found that NCOR1 mRNA was expressed at significantly higher levels in patients over 50 years of age, without axillary lymph node involvement, with tumor size less than 2 cm, with low or intermediate histological grade, with ERalpha/PgR-positive and with HER2 negative tumors. Patients with high levels of expression of NCOR1 mRNA have a better prognosis than those with low expression. Univariate and multivariate prognostic analysis demonstrated that NCOR1 mRNA is an independent prognostic factor for breast cancer.

• Authors: Zhenhuan Zhang, Hiroko Yamashita, Tatsuya Toyama, Hiroshi Sugiura, Yoshiaki Ando, Keiko Mita, Maho Hamaguchi, Yasuo Hara, Shunzo Kobayashi, Hirotaka Iwase
• Journal: Cancer letters (Cancer Lett) Vol. 237 Issue 1 Pg. 123-9 (Jun 08 2006) ISSN: 0304-3835 [Print] Ireland
• PMID: 16019133 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Estrogen Receptor alpha
• NCOR1 protein, human
• Nuclear Proteins
• Nuclear Receptor Co-Repressor 1
• RNA, Messenger
• Receptors, Progesterone
• Repressor Proteins
• Receptor, ErbB-2

Topics

• Adult
• Age Factors
• Aged
• Aged, 80 and over
• Breast Neoplasms (genetics, metabolism, pathology)
• Estrogen Receptor alpha (metabolism)
• Female
• Gene Expression Regulation, Neoplastic
• Humans
• Lymphatic Metastasis
• Middle Aged
• Neoplasm Invasiveness
• Nuclear Proteins (analysis, genetics, metabolism)
• Nuclear Receptor Co-Repressor 1
• Prognosis
• RNA, Messenger (metabolism)
• Receptor, ErbB-2 (metabolism)
• Receptors, Progesterone (metabolism)
• Repressor Proteins (analysis, genetics, metabolism)
• Survival Analysis