Anti-serum amyloid component P antibodies in patients with systemic lupus erythematosus correlate with disease activity.

Abstract

OBJECTIVE:

To determine the presence of raised titres of anti-serum amyloid P component (SAP) antibodies in patients with systemic lupus erythematosus (SLE) and to evaluate their correlation with clinical disease by the SLEDAI and clinical manifestations.

METHODS:

452 samples were screened for raised anti-SAP antibody titres by an ELISA. Clinical measures and SLEDAI scores were independently reviewed from medical records. 21 serial samples from 7 patients with SLE were assessed for a change in anti-SAP antibody titres after treatment.

RESULTS:

Raised anti-SAP antibody titres were detected in 145/328 (44%) SLE samples. In 112 randomly selected samples, 69/112 (62%) patients had raised anti-SAP antibodies and anti-dsDNA antibody titres, whereas only 32/112 (28%) had raised anti-dsDNA antibody titres without raised anti-SAP antibody titres. The mean titre of anti-SAP antibodies in patients with active disease was higher than in patients with inactive disease and controls. SLEDAI scores, assessed in 54 patients, were raised in 26/31 (84%) patients with raised anti-SAP antibody titres. A SLEDAI score >or=8 was found in 16/31 (52%) patients with raised anti-SAP antibody titres but in only 5/23 (22%) patients without raised titres. No specific pattern of disease was detected in patients with or without raised titres of anti-SAP antibodies. Serial sampling from patients with active SLE and raised anti-SAP antibody titres showed that anti-SAP antibody titres decreased after treatment and correlated with clinical improvement.

CONCLUSION:

Raised anti-SAP antibody titres detected in patients with SLE correlate with disease activity and decrease with improvement of clinical disease, and thus may serve as an additional prognostic marker.

• Authors: G Zandman-Goddard, M Blank, P Langevitz, L Slutsky, M Pras, Y Levy, O Shovman, T Witte, A Doria, J Rovensky, Y Shoenfeld
• Journal: Annals of the rheumatic diseases (Ann Rheum Dis) Vol. 64 Issue 12 Pg. 1698-702 (Dec 2005) ISSN: 0003-4967 [Print] England
• PMID: 16014675 (Publication Type: Journal Article, Multicenter Study)

Chemical References

• Antibodies, Antinuclear
• Autoantibodies
• Immunoglobulin G
• Immunoglobulin M
• Serum Amyloid P-Component

Topics

• Adolescent
• Adult
• Aged
• Antibodies, Antinuclear (blood)
• Autoantibodies (blood)
• Cross-Sectional Studies
• Enzyme-Linked Immunosorbent Assay
• Female
• Humans
• Immunoglobulin G (blood)
• Immunoglobulin M (blood)
• Lupus Erythematosus, Systemic (immunology)
• Male
• Middle Aged
• Serum Amyloid P-Component (immunology)
• Severity of Illness Index