Bronchiolitis obliterans organizing pneumonia after bone marrow transplantation: high-resolution computed tomography findings in 4 patients.

Abstract

OBJECTIVE:

To assess the high-resolution computed tomography (HRCT) appearances of bronchiolitis obliterans organizing pneumonia (BOOP) after bone marrow transplantation (BMT).

METHODS:

The HRCT scans obtained in 4 patients (2 men and 2 women, age range: 20-50 years, mean age = 36 years) with biopsy-proven BOOP after BMT were reviewed retrospectively by 2 observers for the presence, extent, and distribution of parenchymal abnormalities.

RESULTS:

All patients demonstrated consolidation and ground-glass opacity. The consolidation was bilateral, patchy, and asymmetric in all patients and was predominantly peribronchovascular in 3 patients and subpleural and peribronchovascular in 1 patient. Ground-glass opacity was patchy and asymmetric in all patients and was bilateral in 3 patients and unilateral in 1 patient. No zonal predominance of either feature could be identified.

CONCLUSIONS:

The predominant HRCT features of BOOP after BMT are bilateral, patchy, and asymmetric consolidation in a predominantly peribronchovascular distribution with associated ground-glass opacity.

• Authors: Jonathan D Dodd, Nestor L Müller
• Journal: Journal of computer assisted tomography (J Comput Assist Tomogr) 2005 Jul-Aug Vol. 29 Issue 4 Pg. 540-3 ISSN: 0363-8715 [Print] United States
• PMID: 16012315 (Publication Type: Case Reports, Journal Article)

Topics

• Adult
• Bone Marrow Transplantation (adverse effects)
• Cryptogenic Organizing Pneumonia (diagnostic imaging, etiology)
• Diagnosis, Differential
• Female
• Humans
• Male
• Middle Aged
• Sensitivity and Specificity
• Tomography, X-Ray Computed