Abstract | PURPOSE OF REVIEW: RECENT FINDINGS: Current literature focuses on the probability of a fibroatrophic mechanism for the development of osteoradionecrosis, rather than the traditional vascular insufficiency mechanism. Because of the evolution of this new idea, as well as a double-blinded, placebo-controlled study finding no benefit from the use of hyperbaric oxygen for advanced osteoradionecrosis of the mandible, new treatment considerations have emerged. Ongoing research is also being conducted to clarify the role of osteoclasts in the pathogenesis of osteoradionecrosis. Restoration of blood supply or vascularized tissue to the affected area continues to be of primary importance in the resolution of osteoradionecrosis. SUMMARY: It is clear that the cause and pathogenesis of osteoradionecrosis are far more complex than originally believed. Current and future research on this multifaceted topic will focus on the cellular basis of this condition, because as it is elucidated, more effective medical treatment regimens will become evident.
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Authors | Marita S Teng, Neal D Futran |
Journal | Current opinion in otolaryngology & head and neck surgery
(Curr Opin Otolaryngol Head Neck Surg)
Vol. 13
Issue 4
Pg. 217-21
(Aug 2005)
ISSN: 1068-9508 [Print] United States |
PMID | 16012245
(Publication Type: Journal Article, Review)
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Topics |
- Disease Progression
- Head and Neck Neoplasms
(radiotherapy)
- Humans
- Incidence
- Mandible
(pathology)
- Mandibular Diseases
(epidemiology, etiology, therapy)
- Osteoradionecrosis
(epidemiology, etiology, therapy)
- Radiotherapy, Adjuvant
(adverse effects)
- Risk Factors
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