Restin: a novel intermediate filament-associated protein highly expressed in the Reed-Sternberg cells of Hodgkin's disease.

We have identified a cDNA coding for a protein of 160 kDa which is expressed in in vitro cultured human peripheral blood monocytes. The predicted amino acid sequence contains an alpha-helical rod domain possessing features characteristic of intermediate filament proteins. However, the immunocytochemical staining pattern, abundance and solubility in Triton X-100/high salt buffers suggest that this protein is probably only associated with the intermediate filament network and represents a new type of intermediate filament associated protein. In a survey of normal, inflammatory and human tumour tissue samples, this protein, which we have named restin, was found to be highly expressed in Reed-Sternberg cells, the tumoral cells diagnostic for Hodgkin's disease. We suggest that restin overexpression may be a contributing factor in the progression of Hodgkin's disease.
AuthorsG Bilbe, J Delabie, J Brüggen, H Richener, F A Asselbergs, N Cerletti, C Sorg, K Odink, L Tarcsay, W Wiesendanger
JournalThe EMBO journal (EMBO J) Vol. 11 Issue 6 Pg. 2103-13 (Jun 1992) ISSN: 0261-4189 [Print] ENGLAND
PMID1600942 (Publication Type: Comparative Study, Journal Article)
Chemical References
  • DNA, Neoplasm
  • Intermediate Filament Proteins
  • Microtubule-Associated Proteins
  • Neoplasm Proteins
  • Vimentin
  • cytoplasmic linker protein 170
  • Amino Acid Sequence
  • Animals
  • Base Sequence
  • CHO Cells
  • Cell Line
  • Cells, Cultured
  • Cloning, Molecular
  • Cricetinae
  • DNA, Neoplasm (genetics, isolation & purification)
  • Gene Library
  • Hodgkin Disease (genetics, metabolism)
  • Humans
  • Intermediate Filament Proteins (genetics, isolation & purification, metabolism)
  • Microtubule-Associated Proteins
  • Molecular Sequence Data
  • Monocytes (cytology, metabolism, pathology)
  • Neoplasm Proteins (genetics, isolation & purification, metabolism)
  • Protein Conformation
  • Reed-Sternberg Cells (metabolism)
  • Sequence Homology, Nucleic Acid
  • Transfection
  • Vimentin (analysis)

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