Relationship between matrix metalloproteinase-2 activity and cystatin C levels in patients with hepatic disease.

Abstract

OBJECTIVES:

A direct relationship between cystatin C levels and the severity of hepatic disease has been revealed in our previous study. This study was aimed to consider whether a correlation exists between matrix metalloproteinases (MMPs), which have been proven to be involved in liver cirrhosis, and cystatin C to reflect the severity of hepatic disease.

DESIGN AND METHODS:

A total of 154 consecutive patients with various liver diseases were recruited to determine their serum levels of cystatin C, MMP-2 and-9, together with other hepatic parameters. These were compared with 40 normal controls.

RESULTS:

Average levels of MMP-2 and cystatin C were significantly higher in patients while MMP-9 was significantly lower, as compared to controls. A linear regression analysis has revealed a direct relationship between cystatin C and MMP-2 (Y=83.39 + 270.56 X, R=0.38, P< 0.001), as well as between MMP-2 and the severity of liver diseases.

CONCLUSION:

This is the first study to demonstrate a correlation between cystatin C and MMP-2, suggesting that there may be certain interactions between cystatin C and MMP-2 in patients with hepatic diseases.

• Authors: Tzy-Yen Chen, Yih-Shou Hsieh, Chi-Chieh Yang, Chi-Ping Wang, Shun-Fa Yang, Yan-Wen Cheng, Hui-Ling Chiou
• Journal: Clinical biochemistry (Clin Biochem) Vol. 38 Issue 7 Pg. 632-8 (Jul 2005) ISSN: 0009-9120 [Print] United States
• PMID: 16009142 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• CST3 protein, human
• Cystatin C
• Cystatins
• Aspartate Aminotransferases
• Alanine Transaminase
• Matrix Metalloproteinase 2
• Matrix Metalloproteinase 9

Topics

• Alanine Transaminase (blood)
• Aspartate Aminotransferases (blood)
• Cross-Sectional Studies
• Cystatin C
• Cystatins (blood)
• Humans
• Liver Diseases (blood, diagnosis)
• Matrix Metalloproteinase 2 (blood)
• Matrix Metalloproteinase 9 (blood)