[Experimental study on anti-inflammatory and analgesic effects of Yitieling Paste].

Abstract

OBJECTIVE:

To observe the anti-inflammatory and analgesic effects of Yitieling Paste (YTLP).

METHODS:

YTLP and aspirin (as a control drug) were introduced to treat the edematous ears of mice induced by xylene and swollen toes of mice induced by carrageenin, and to relieve the pain in mice induced by heat and acetic acid. The swelling degree, pain threshold and body distortions were measured.

RESULTS:

The repression rates of the ear edema in groups of YTLP of high and low dosages and the aspirin group were 67.92%, 52.52% and 58.28%, respectively. The repression rate of the toe swelling in YTLP high dosage group was higher than that of the aspirin group, which was higher than that of the YTLP low dosage group. The results of analgesic effect of the three YTLP-treated groups showed that with the increase of dosage, the pain thresholds were higher and higher, and the body distortions were lower and lower. The pain thresholds of high and medium dosage YTLP groups were near to the aspirin group.

CONCLUSION:

YTLP possesses a strong anti-inflammatory and analgesic effect.

• Authors: Li-Jun Xu, Yong-Hong Hu, Fu-Er Lu, Xin Zou
• Journal: Zhong xi yi jie he xue bao = Journal of Chinese integrative medicine (Zhong Xi Yi Jie He Xue Bao) Vol. 3 Issue 4 Pg. 303-6 (Jul 2005) ISSN: 1672-1977 [Print] China
• PMID: 16009112 (Publication Type: English Abstract, Journal Article)

Chemical References

• Analgesics
• Anti-Inflammatory Agents, Non-Steroidal
• Drugs, Chinese Herbal

Topics

• Administration, Topical
• Analgesics (pharmacology)
• Animals
• Anti-Inflammatory Agents, Non-Steroidal (pharmacology)
• Drugs, Chinese Herbal (pharmacology)
• Edema (pathology, physiopathology)
• Female
• Male
• Mice
• Pain (pathology, physiopathology)
• Pain Threshold
• Random Allocation
• Rats