Toxic epidermal necrolysis secondary to angioimmunoblastic T-cell lymphoma.

Abstract

A 67-year-old man presented with a history of lymphadenopathy, fevers and separate skin eruptions of erythrodermic spongiotic dermatitis initially and subsequent toxic epidermal necrolysis. Initial lymph node biopsies showed non-specific granulomatous changes, and skin biopsies and bone marrow aspirate were not diagnostic. His toxic epidermal necrolysis responded well to 3 days of intravenous immunoglobulin. The patient was discharged from hospital and reviewed regularly as an outpatient. Due to persisting lymphadenopathy, further lymph node biopsy led to the diagnosis of angioimmunoblastic T-cell lymphoma, a rare form of peripheral T-cell lymphoma with a poor prognosis. At the time of diagnosis his condition deteriorated rapidly and he died soon after.

• Authors: Brad Jones, Yin Vun, Muna Sabah, Conleth A Egan
• Journal: The Australasian journal of dermatology (Australas J Dermatol) Vol. 46 Issue 3 Pg. 187-91 (Aug 2005) ISSN: 0004-8380 [Print] Australia
• PMID: 16008654 (Publication Type: Case Reports, Journal Article)

Chemical References

• Immunoglobulins, Intravenous

Topics

• Aged
• Fatal Outcome
• Head and Neck Neoplasms (complications, diagnosis)
• Humans
• Immunoblastic Lymphadenopathy (complications, diagnosis)
• Immunoglobulins, Intravenous (therapeutic use)
• Lymph Nodes (pathology)
• Lymphoma, T-Cell (complications, diagnosis)
• Male
• Stevens-Johnson Syndrome (diagnosis, drug therapy, etiology)