Inhibitory effect of topical application of a green tea polyphenol fraction on tumor initiation and promotion in mouse skin.

Abstract

A green tea polyphenol fraction was evaluated for its ability to inhibit tumor initiation by polycyclic aromatic hydrocarbons and tumor promotion by a phorbol ester in the skin of CD-1 mice. Topical application of the green tea polyphenol fraction inhibited benzo[a]pyrene- and 7,12-dimethylbenz[a]-anthracene-induced tumor initiation as well as 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced tumor promotion. Topical application of the green tea polyphenol fraction also inhibited TPA-induced inflammation, ornithine decarboxylase activity, hyperplasia and hydrogen peroxide formation. Studies with individual polyphenolic compounds in green tea indicated that topical application of (-)-epigallocatechin gallate, (-)-epigallocatechin and (-)-epicatechin gallate inhibited TPA-induced inflammation in mouse epidermis.

• Authors: M T Huang, C T Ho, Z Y Wang, T Ferraro, T Finnegan-Olive, Y R Lou, J M Mitchell, J D Laskin, H Newmark, C S Yang
• Journal: Carcinogenesis (Carcinogenesis) Vol. 13 Issue 6 Pg. 947-54 (Jun 1992) ISSN: 0143-3334 [Print] England
• PMID: 1600615 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Phenols
• Tea
• Benzo(a)pyrene
• 9,10-Dimethyl-1,2-benzanthracene
• Hydrogen Peroxide
• Ornithine Decarboxylase
• Tetradecanoylphorbol Acetate

Topics

• 9,10-Dimethyl-1,2-benzanthracene
• Administration, Topical
• Animals
• Benzo(a)pyrene
• Edema (chemically induced, prevention & control)
• Enzyme Induction (drug effects)
• Female
• Flow Cytometry
• Hydrogen Peroxide (metabolism)
• Hyperplasia (chemically induced)
• Mice
• Ornithine Decarboxylase (biosynthesis)
• Phenols (administration & dosage, chemistry, isolation & purification, pharmacology)
• Skin (metabolism, pathology)
• Skin Neoplasms (chemically induced, pathology, prevention & control)
• Tea (chemistry)
• Tetradecanoylphorbol Acetate