| Abstract | The rebirth of interest in suppressor T cells has spawned a vast amount of data that shed light on their biology and role in immune system homeostasis. Since the early studies on the naturally occurring CD4+/CD25+ T regulatory cells, much attention has been focused on ways to induce suppressor T cells in vivo. This review discusses the salient features of the induction of antigen-specific suppressor T cells in a T cell receptor (TCR) transgenic mouse model of experimental allergic encephalomyelitis (EAE) in response to epicutaneous immunization with cognate peptide. We discuss the skin environment as a privileged anatomical site for therapeutic intervention against pro-inflammatory auto-immune disorders using non-invasive approaches for antigen delivery. |
| Authors | Margaret S Bynoe, Christophe Viret
(Affiliation: Section of Immunobiology, Yale University School of Medicine, and Howard Hughes Medical Institute, 300 Cedar St., New Haven, CT 06520-8011, USA. Margaret.bynoe at yale.edu)
|
| Journal | Journal of neuroimmunology
(J Neuroimmunol)
Vol. 167
Issue 1-2
Pg. 4-12
(Oct 2005)
ISSN: 0165-5728 Netherlands |
| PMID | 16005985
(Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S., Review)
|
| Chemical References |
|
| Topics |
- Administration, Cutaneous
- Animals
- Antigens
(administration & dosage, immunology)
- CD8-Positive T-Lymphocytes
(immunology)
- Disease Models, Animal
- Encephalomyelitis, Autoimmune, Experimental
(immunology)
- Humans
- Immunization
- T-Lymphocytes, Regulatory
(immunology)
|
