Abstract |
The rd7mouse is a mutant mouse with a relatively late development of retinal degeneration. Earlier studies have shown that rd7 mice have a distinctive pattern of retinal dysplasia with an increased number of cone cells, particularly those with S ( short wavelength)-opsin immunoreactivity. These alterations of the rd7 retina are caused by a mutation in the photoreceptor cell-specific nuclear receptor gene, Nr2e3, which is involved in the signaling pathway regulating photoreceptor cell differentiation, cell maintenance, and cell-cell interactions. The purpose of this study was to determine the physiological properties of the rd7 retina using electroretinographic (ERG) techniques. We found that the maximal a-wave amplitude of the ERG in rd7 mice was already reduced to half of the congenic controls at 6 weeks of age with normal phototransduction sensitivity. The photopic ERGs of rd7 mice were not supernormal, and the amplitudes of the S-cone ERGs were not significantly different from those recorded in controls. These results suggested that even though the number of cones expressing S- opsin is increased, the physiological function of the S-cone system is not enhanced in rd7 mice.
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Authors | Shinji Ueno, Mineo Kondo, Kentaro Miyata, Toshie Hirai, Takaki Miyata, Jiro Usukura, Yuji Nishizawa, Yozo Miyake |
Journal | Experimental eye research
(Exp Eye Res)
Vol. 81
Issue 6
Pg. 751-8
(Dec 2005)
ISSN: 0014-4835 [Print] England |
PMID | 16005871
(Publication Type: Journal Article)
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Chemical References |
- Eye Proteins
- Nr2e3 protein, mouse
- Orphan Nuclear Receptors
- Receptors, Cytoplasmic and Nuclear
- Rod Opsins
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Topics |
- Animals
- Dark Adaptation
- Electroretinography
- Eye Proteins
(genetics)
- Genotype
- Mice
- Mice, Inbred C57BL
- Mice, Mutant Strains
- Mutation
- Orphan Nuclear Receptors
- Receptors, Cytoplasmic and Nuclear
(genetics)
- Retinal Cone Photoreceptor Cells
(physiopathology)
- Retinal Degeneration
(genetics, pathology, physiopathology)
- Rod Opsins
(metabolism)
- Vision, Ocular
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