Physiological function of S-cone system is not enhanced in rd7 mice.

The rd7mouse is a mutant mouse with a relatively late development of retinal degeneration. Earlier studies have shown that rd7 mice have a distinctive pattern of retinal dysplasia with an increased number of cone cells, particularly those with S (short wavelength)-opsin immunoreactivity. These alterations of the rd7 retina are caused by a mutation in the photoreceptor cell-specific nuclear receptor gene, Nr2e3, which is involved in the signaling pathway regulating photoreceptor cell differentiation, cell maintenance, and cell-cell interactions. The purpose of this study was to determine the physiological properties of the rd7 retina using electroretinographic (ERG) techniques. We found that the maximal a-wave amplitude of the ERG in rd7 mice was already reduced to half of the congenic controls at 6 weeks of age with normal phototransduction sensitivity. The photopic ERGs of rd7 mice were not supernormal, and the amplitudes of the S-cone ERGs were not significantly different from those recorded in controls. These results suggested that even though the number of cones expressing S-opsin is increased, the physiological function of the S-cone system is not enhanced in rd7 mice.
AuthorsShinji Ueno, Mineo Kondo, Kentaro Miyata, Toshie Hirai, Takaki Miyata, Jiro Usukura, Yuji Nishizawa, Yozo Miyake
JournalExperimental eye research (Exp Eye Res) Vol. 81 Issue 6 Pg. 751-8 (Dec 2005) ISSN: 0014-4835 [Print] England
PMID16005871 (Publication Type: Journal Article)
Chemical References
  • Eye Proteins
  • Nr2e3 protein, mouse
  • Orphan Nuclear Receptors
  • Receptors, Cytoplasmic and Nuclear
  • Rod Opsins
  • Animals
  • Dark Adaptation
  • Electroretinography
  • Eye Proteins (genetics)
  • Genotype
  • Mice
  • Mice, Inbred C57BL
  • Mice, Mutant Strains
  • Mutation
  • Orphan Nuclear Receptors
  • Receptors, Cytoplasmic and Nuclear (genetics)
  • Retinal Cone Photoreceptor Cells (physiopathology)
  • Retinal Degeneration (genetics, pathology, physiopathology)
  • Rod Opsins (metabolism)
  • Vision, Ocular

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