Abstract | AIM: METHODS: Forty-four patients with sinonasal papilloma and invasive SCC were selected. The nasal tissues were stained with monoclonal antibodies to EGFR, TGF-alpha and Ki-67. The results were analysed using quantitative immunohistochemical analysis. In situ hybridization studies for HPV DNA for 6/11, 16/18 and 31/33 were also performed on the tissue. RESULTS: Significant increase of EGFR and TGF-alpha was observed in IP with severe dysplasia, IP with carcinoma and invasive SCC compared to IP with mild dysplasia and control nasal mucosa. And a serial upreguration in terms of Ki-67 index in IP with dysplasia was observed. Among IP, HPV 6/11-positive was present in 42% tumour and HPV 16/18-positive was present in 31% of tumours. Among HPV 6/11 and 16/18-positive IP, significant increase of EGFR and Ki-67 index were observed. CONCLUSION: Pre-cancerous lesions of IP exhibited elevated levels of EGFR and TGF-alpha and these expression may be associated with early events in IP carcinogenesis. HPV infection may be an early event in a multistep process of malignant formation of IP.
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Authors | H Katori, A Nozawa, M Tsukuda |
Journal | European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology
(Eur J Surg Oncol)
Vol. 31
Issue 8
Pg. 905-11
(Oct 2005)
ISSN: 0748-7983 [Print] England |
PMID | 16005600
(Publication Type: Comparative Study, Journal Article)
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Chemical References |
- Antibodies, Monoclonal
- Biomarkers, Tumor
- Ki-67 Antigen
- Transforming Growth Factor alpha
- ErbB Receptors
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Topics |
- Antibodies, Monoclonal
- Biomarkers, Tumor
(analysis)
- Carcinoma
(pathology)
- Carcinoma, Squamous Cell
(pathology)
- Cell Transformation, Neoplastic
(pathology)
- ErbB Receptors
(analysis)
- Female
- Humans
- In Situ Hybridization
- Ki-67 Antigen
(analysis)
- Male
- Middle Aged
- Nasal Mucosa
(pathology)
- Neoplasm Invasiveness
- Nose Neoplasms
(pathology)
- Papilloma
(pathology)
- Papilloma, Inverted
(pathology)
- Papillomaviridae
(classification, isolation & purification)
- Paranasal Sinus Neoplasms
(pathology)
- Precancerous Conditions
(pathology)
- Transforming Growth Factor alpha
(analysis)
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