Abstract |
Subjects were 20 patients with tongue cancer treated between April 1996 and December 2002 with intraarterial infusion of cisplatin (60-120 mg/m2) (and docetaxel 10-30 mg/m2) and intravenous infusion of sodium thiosulfate followed by 5-fluorouracil (5-FU) (800-1000 mg/m2) for 3 to 5 days. All patients underwent radiation (50-80 Gy). Ten had stage II, 4 stage III, and 6 stage IV A disease. Complete response at the primary site was achieved in 50% for T2, 67% for T3, and 0% for T4 lesions in those undergoing IA cisplatin followed by systemic 5-FU with concurrent radiation. Complete response at the primary site was achieved in all patients given IA cisplatin and docetaxel followed by systemic 5-FU with concurrent radiation. Disease-specific survival was 75% and overall survival 69% at 5 years. Side effects of treatment were tolerable, except for grade three radiomucositis in 70% of patients and grade three bone marrow depression in one treated with weekly IA chemotherapy.
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Authors | Sohei Endo, Shin Suzuki, Kenzo Tsuji, Hideo Niwa, Yugo Noguchi, Kenji Yoshida, Akinori Kida, Yoshiaki Tanaka, Kazuhisa Himi, Akiko Takemoto |
Journal | Nihon Jibiinkoka Gakkai kaiho
(Nihon Jibiinkoka Gakkai Kaiho)
Vol. 108
Issue 6
Pg. 689-93
(Jun 2005)
ISSN: 0030-6622 [Print] Japan |
PMID | 16001727
(Publication Type: Journal Article)
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Chemical References |
- Taxoids
- Thiosulfates
- Docetaxel
- sodium thiosulfate
- Cisplatin
- Fluorouracil
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Topics |
- Antineoplastic Combined Chemotherapy Protocols
(therapeutic use)
- Cisplatin
(administration & dosage)
- Combined Modality Therapy
- Docetaxel
- Female
- Fluorouracil
(administration & dosage)
- Humans
- Infusions, Intra-Arterial
- Male
- Middle Aged
- Prognosis
- Retrospective Studies
- Taxoids
(administration & dosage)
- Thiosulfates
(administration & dosage)
- Tongue Neoplasms
(drug therapy, radiotherapy)
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