Abstract | PURPOSE: EXPERIMENTAL DESIGNS: Prostate specimens from 36 men were procured preserving blood flow to prevent ischemia and cyropreserved immediately. Recurrent prostate cancer specimens from 18 men whose cancer recurred locally during androgen deprivation therapy and androgen-stimulated benign prostate specimens from 18 men receiving no hormonal treatments were studied. Tissue levels of testosterone and dihydrotestosterone were measured in each specimen using liquid chromatography/electrospray tandem mass spectrometry. Testosterone and dihydrotestosterone levels were compared with clinical variables and treatment received. RESULTS: CONCLUSIONS:
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Authors | Mark A Titus, Michael J Schell, Fred B Lih, Kenneth B Tomer, James L Mohler |
Journal | Clinical cancer research : an official journal of the American Association for Cancer Research
(Clin Cancer Res)
Vol. 11
Issue 13
Pg. 4653-7
(Jul 01 2005)
ISSN: 1078-0432 [Print] United States |
PMID | 16000557
(Publication Type: Comparative Study, Journal Article, Research Support, N.I.H., Extramural, Research Support, U.S. Gov't, P.H.S.)
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Chemical References |
- Dihydrotestosterone
- Testosterone
|
Topics |
- Aged
- Aged, 80 and over
- Chromatography, High Pressure Liquid
(methods)
- Dihydrotestosterone
(analysis)
- Humans
- Male
- Middle Aged
- Neoplasm Metastasis
- Neoplasm Recurrence, Local
- Prostatic Neoplasms
(metabolism, pathology)
- Radioimmunoassay
(methods)
- Spectrometry, Mass, Electrospray Ionization
(methods)
- Survival Analysis
- Testosterone
(analysis)
|