Involvement of streptococcal mitogenic exotoxin Z in streptococcal toxic shock syndrome.

Abstract

We report a nonfatal case of streptococcal toxic shock syndrome (STSS) caused by a Streptococcus pyogenes emm118 strain encoding a novel variant of streptococcal mitogenic exotoxin Z (SMEZ-34). This variant was responsible for the major mitogenic activity in the cell culture supernatant. Patient sera showed seroconversion toward SMEZ, implying a role for this toxin in STSS.

• Authors: Lily Yang, Mark Thomas, Andrew Woodhouse, Diana Martin, John D Fraser, Thomas Proft
• Journal: Journal of clinical microbiology (J Clin Microbiol) Vol. 43 Issue 7 Pg. 3570-3 (Jul 2005) ISSN: 0095-1137 [Print] United States
• PMID: 16000510 (Publication Type: Case Reports, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Antigens, Bacterial
• Bacterial Outer Membrane Proteins
• Bacterial Toxins
• Carrier Proteins
• Exotoxins
• mitogenic exotoxin Z protein, Streptococcus
• streptococcal M protein

Topics

• Adult
• Antigens, Bacterial (genetics, metabolism)
• Bacterial Outer Membrane Proteins (genetics, metabolism)
• Bacterial Toxins (genetics, metabolism)
• Carrier Proteins (genetics, metabolism)
• Exotoxins (genetics, metabolism)
• Female
• Humans
• Molecular Sequence Data
• Sequence Analysis, DNA
• Shock, Septic (microbiology, physiopathology)
• Streptococcus pyogenes (classification, genetics, metabolism, pathogenicity)