| Abstract | AIMS: Resistin is an adipocyte-derived factor implicated in obesity-associated type 2 diabetes (T2DM). This study examines the association between human serum resistin, T2DM and coronary heart disease. METHODS: One hundred and fourteen Saudi Arabian patients (male: female ratio 46:68; age 51.4 (mean +/- SD)11.7 years; median and range: 45.59 (11.7) years and BMI: 27.1 (mean +/- SD) 8.1 Kgm2 median and range: 30.3 (6.3) were studied. Serum resistin and C-reactive protein (CRP), a marker of inflammation CRP levels, were measured in all subjects. (35 patients had type 2 diabetes mellitus (T2DM); 22 patients had coronary heart disease (CHD). RESULTS: Serum resistin levels were 1.2-fold higher in type 2 diabetes and 1.3-fold higher in CHD than in controls (p = 0.01). In addition, CRP was significantly increased in both T2DM and CHD patients (p = 0.007 and p = 0.002 respectively). The use of regression analysis also determined that serum resistin correlated with CRP levels (p = 0.04, R2 0.045). CONCLUSION: The findings from this study further implicate resistin as a circulating protein associated with T2DM and CHD. In addition this study also demonstrates an association between resistin and CRP, a marker of inflammation in type 2 diabetic patients. |
| Authors | N Al-Daghri, R Chetty, P G McTernan, K Al-Rubean, O Al-Attas, A F Jones, S Kumar
(Affiliation: Biochemistry Department, King Saud University College of Science, Riyadh, Saudi Arabia. aldaghri2000 at hotmail.com)
|
| Journal | Cardiovascular diabetology
(Cardiovasc Diabetol)
Vol. 4
Issue 1
Pg. 10
( 2005)
ISSN: 1475-2840 England |
| PMID | 15998471
(Publication Type: Journal Article)
|
| Chemical References |
- Biological Markers
- Blood Glucose
- Cholesterol, LDL
- Resistin
- C-Reactive Protein
|
| Topics |
- Adult
- Biological Markers
(blood)
- Blood Glucose
(analysis)
- C-Reactive Protein
(analysis)
- Case-Control Studies
- Cholesterol, LDL
(blood)
- Cohort Studies
- Coronary Artery Disease
(blood)
- Data Interpretation, Statistical
- Diabetes Mellitus, Type 2
(blood)
- Female
- Humans
- Insulin Resistance
- Male
- Middle Aged
- Radioimmunoassay
- Regression Analysis
- Resistin
(blood)
- Saudi Arabia
|
