[Mechanisms of action in bisphosphonates].

Abstract

Bisphosphonates have the high affinity to hydroxyapatites and act as the inhibition of bone resorption in a low dose, while they act as the inhibition of the calcification in a high dose. In tissues, bisphosphonates adsorbing bone surface become detached by a low pH environment with bone resorption and then act on osteoclasts. In cellular events, nitrogen-containing compounds interfere with protein prenylation by inhibiting an enzyme in the HMG-CoA reductase pathway. On the other hand, non-nitrogen-containing bisphosphonates act by producing toxic analogs of ATP that cause cell death.

• Authors: Hironobu Hoshino, Kaoru Yamazaki
• Journal: Clinical calcium (Clin Calcium) Vol. 15 Issue 7 Pg. 88-92 (Jul 2005) ISSN: 0917-5857 [Print] Japan
• PMID: 15995302 (Publication Type: English Abstract, Journal Article, Review)

Chemical References

• Diphosphonates

Topics

• Bone Resorption (drug therapy)
• Diphosphonates (pharmacology)
• Humans
• Osteoclasts (drug effects)
• Structure-Activity Relationship