To evaluate the expressions of apoptotic signal
proteins FADD, TRADD, FasL, Fas, and NFkappaB in gastric
carcinoma tissues and their clinical significance.
METHODS: Western blot immune trace method was adopted to detect the expressions of apoptotic signal
proteins FADD, TRADD, FasL, Fas, and NFkappaB in 55 tissue specimens of gastric
carcinoma.
RESULTS: Five apoptotic signal
proteins had different expressions in the gastric
carcinoma samples and their expressions were not correlated to age (P = 0.085). Expressions of the FADD, FasL, Fas, and NFkappaB
proteins reduced with increase of the volume of
tumor with the exception of increased expression the
TRADD protein (64.7-71.1%, P = 0.031). With gradual increase of the
malignancy of gastric
carcinoma tissues, expressions of the FADD, FasL, and Fas
proteins decreased (78.6-28.0%, P = 0.008; 78.6-65.9%, P = 0.071; 100.0-46.3%, P = 0.014), while expressions of the TRADD and NFkappaB
proteins increased (42.9-78.1%, P = 0.063; 78.6-79.1%, P = 0.134). With gradual increase of serum CEA, expression of the FADD
protein decreased (62.5-34.0%, P = 0.073), but expressions of the TRADD, FasL, Fas, and NFkappaB
proteins increased (0.0-80.8%, P = 0.005; 62.5-70.2%, P = 0.093; 0.0-70.2%, P = 0.003; 62.5-80.9%, P = 0.075). When compared to the tissues of gastric
carcinoma without
metastasis, the positive rate of expressions of the FADD and FasL
proteins increased, whereas expressions of the TRADD, FADD, and NFkappaB
proteins decreased. There was no significant difference between them (P = 0.095).
CONCLUSION: